Kallikrein
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Kallikrein Related Products (55)
Related Products (55)
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Avoralstat
0 ImagesCat. No.: HY-16735CAS No.: 918407-35-9Synonyms: BCX4161Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research.
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Kallikrein 5-IN-2
0 ImagesKallikrein 5-IN-2 (compound 21) is a selective Kallikrein KLK5 inhibitor (pIC50=7.1). KLK5 inhibition may normalise epidermal shedding and reduce the associated inflammation and itching.
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Pro-Phe-Arg-AMC acetate
0 ImagesPro-Phe-Arg-AMC acetate is a substrate for human glandular kallikrein 2. Pro-Phe-Arg-AMC acetate can be used for the quantitative detection of enzyme activity.
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Sebetralstat
0 ImagesSynonyms: KVD900Sebetralstat (KVD900) is an orally active and selective plasma kallikrein inhibitor, with an IC50 of 6.0 nM and a Ki of 3.0 nM against the human target. Sebetralstat binds to the active site of plasma kallikrein, inducing a conformational flip of Trp215 to form a U-shaped conformation; its P1 group interacts with the S1 pocket through hydrophobic interactions and displacement of high-energy water molecules, independent of the Asp189 ionic bond. Sebetralstat inhibits plasma kallikrein-kinin system activation in whole plasma, rapidly relieves laryngeal and abdominal attack symptoms of hereditary angioedema (HAE-C1INH), and reduces attack severity. Sebetralstat can be used in research related to hereditary angioedema (HAE).
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D-Pro-Phe-Arg-Chloromethylketone
0 ImagesD-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma kallikrein, plays an important role in thrombosis and inflammation.
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JNJ-pan-AR
0 ImagesCat. No.: HY-183667CAS No.: 1332390-06-3JNJ-pan-AR is an orally active androgen receptor (AR) inhibitor with an IC50 of 19 nM and a Ki of 8.4 nM against human wild-type AR. JNJ-pan-AR abolishes androgen-induced KLK2 and KLK3 mRNA expression and reduces androgen-dependent colony formation in prostate cancer cells. JNJ-pan-AR blocks AR nuclear translocation, inhibits PSA protein expression, and represses the growth of AR-dependent tumor cells and ARF877L-driven tumor xenografts. JNJ-pan-AR blocks transactivation and signaling of wild-type AR and various mutant AR variants. JNJ-pan-AR is applicable for research on castration-resistant prostate cancer.
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Anti-KLK7 Antibody
0 ImagesCat. No.: HY-P992250
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Lanadelumab
0 ImagesSynonyms: SHP643; DX-2930; X124-G01Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema.
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Berotralstat
0 ImagesSynonyms: BCX7353Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.
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Pro-Phe-Arg-AMC
0 ImagesPro-Phe-Arg-AMC is a substrate for human glandular kallikrein 2. Pro-Phe-Arg-AMC can be used for the quantitative detection of enzyme activity.
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Ecallantide TFA
0 ImagesCat. No.: HY-108814APurity: 99.54%Synonyms: DX-88 TFAEcallantide (DX-88) TFA is a specific recombinant plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide may be used to prevent acute attacks of angioedema.
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D-Val-Leu-Arg-pNA acetate
0 ImagesD-Val-Leu-Arg-pNA (acetate) is the acetate form of D-Pro-Phe-Arg-p-nitroanilide (pNa). D-Pro-Phe-Arg-p-nitroanilide (pNa) is the substrate for kallikrein and can be used to assay the activity of kallikrein.
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PKSI-527
0 ImagesPKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system.
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PPACK II diTFA
0 ImagesCat. No.: HY-122543CAS No.: 649748-23-2PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor.
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KKI-5 TFA
0 ImagesCat. No.: HY-P0237APurity: 99.29%KKI-5 (TFA) is a specific inhibitor of tissue kallikrein. KKI-5 (TFA) can attenuate breast cancer cell invasion.
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Feniralstat
0 ImagesSynonyms: KVD-824Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM).
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Berotralstat dihydrochloride
0 ImagesSynonyms: BCX7353 dihydrochlorideBerotralstat dihydrochloride (BCX7353 dihydrochloride) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.
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Plasma kallikrein-IN-4
0 ImagesPlasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC50 of 0.016 μM against human plasma kallikrein.
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LSP-249
0 ImagesLSP-249 (example 35), extracted from patent WO2016011209A1, is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell.
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KVD-001
0 ImagesKVD-001 is a potent plasma kallikrein inhibitor. KVD-001 can be used for diabetic macular edema research.
