918407-35-9
918407-35-9
Chemical Structure
Avoralstat
Synonym(s): BCX4161
- CAS No.: 918407-35-9
- Formula:C28H27N5O5
- Molecular Weight:513.54
IUPAC Name: 3-(2-((4-carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinic acid
InChIKey: TUWMKPVJGGWGNL-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C(NCC2CC2)=O)=CC=C1C3=CC(OC)=C(C=C)C=C3C(NC4=CC=C(C(N)=N)C=C4)=O)O
Biological Activity: Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Avoralstat | 98.36% | Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.51
HY-172905BCX-3607 -
Similarity Score 0.46
HY-124838EG1 -
Similarity Score 0.46
HY-145287S-MGB-234 -
Similarity Score 0.46
HY-16682AGN 196996 -
Similarity Score 0.46
HY-12631BMS-654457 -
Similarity Score 0.45
HY-117143TK05 -
Similarity Score 0.45
HY-164523PV1162 -
Similarity Score 0.45
HY-164523A(E/Z)-PV1162 -
Similarity Score 0.45
HY-157889ZINC000028464438 -
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References
- [1]. Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5. [Content Brief]
- [2]. Cornpropst M, et al. Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study. Allergy. 2016;71(12):1676-1683. [Content Brief]
