1426055-14-2
1426055-14-2
Chemical Structure
Lanadelumab
Synonym(s): SHP643; DX-2930; X124-G01
- CAS No.: 1426055-14-2
- Formula:N/A
- Molecular Weight:(145.72 kDa)
IUPAC Name: L-lysine-13C6 hydrochloride
SMILES: [Lanadelumab]
Biological Activity: Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lanadelumab | 99.74% | Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema. | ||||||||||||||||||||
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References
- [1]. Riedl MA, et al. Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks. Allergy. 2020 Nov;75(11):2879-2887. [Content Brief]
- [2]. Kenniston JA, et al. Inhibition of plasma kallikrein by a highly specific active site blocking antibody. J Biol Chem. 2014 Aug 22;289(34):23596-608. [Content Brief]
Keywords
