Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1007):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W440936

Stearic acid-PEG5000-Rhodamine
Stearic acid-PEG5000-Rhodamine is a fatty acid containing PEG polymer which can self assemble in an aqueous solution to form micelles. The polymer can be used to prepare nanoparticles for drug encapsulation. The red dye rhodamine can be easily traced by fluorescence microscopy. Rhodamine has maximum absorption at 570 nm and emission around 595 nm.

HY-W440934

Stearic acid-PEG2000-Rhodamine
Stearic acid-PEG2000-Rhodamine is an amphiphilic PEG polymer which can form micelles in water. The rhodamine can be used for staining sample and easily traced by fluorescence microscopy. Rhodamine has maximum absorption at 570 nm and emission around 595 nm.

HY-159869

G0-C14 analog
G0-C14 analog is a G0-C14 derivative. G0-C14 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles (LNP).

HY-175115

1-Stearoyl-2-17(S)-HDoTE-sn-glycero-3-PE
1-Stearoyl-2-17(S)-HDoTE-sn-glycero-3-PE is a phospholipid. 1-Stearoyl-2-17(S)-HDoTE-sn-glycero-3-PE contains Stearic acid (HY-B2219) and the oxidized adrenic acid metabolite 17(S)-HDoTE (HY-168774) at the sn-1 and sn-2 positions, respectively.

HY-B1555R

Benzyl nicotinate (Standard)
Benzyl nicotinate (Standard) is the analytical standard of Benzyl nicotinate. This product is intended for research and analytical applications. Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow.

HY-164579

NH2-GG-DSPE
NH2-GG-DSPE is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.

HY-155925

DMPE-PEG550 ammonium
DMPE-PEG550 ammonium (14:0 PEG550 PE ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-172925

CP-LC-1447
CP-LC-1447 is an ionizable cationic amino lipid derived from homocysteine.

HY-175148

Hexa lipid 114
Hexa lipid 114 is an ionizable cationic lipid and a derivative of lipid 114 (HY-171900).

HY-153376

LNP Lipid-6
LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP).

HY-W800782

DC-6-14
DC-6-14 is a cationic lipid with gene transfection activity, which can be used for the synthesis of liposomes.

HY-W440913

DSPE-PEG5000-Cy5
DSPE-PEG-Cy5, MW 5000 is a fluorescently labeled PEGylated phospholipid with a molecular weight of 5000 Da. After intravenous injection, DSPE-PEG-Cy5, MW 5000 shows only extremely low fluorescence accumulation at tumor sites in orthotopic tumor-bearing mice, and can be used as a negative control for evaluating tumor accumulation of nanoparticles. DSPE-PEG-Cy5, MW 5000 can serve as a fluorescent marker to prepare Cy5-labeled NPs-DPPA and NPs-DPPA (C3F8) for pharmacokinetic and biodistribution studies in mice. DSPE-PEG-Cy5, MW 5000 is widely applicable to research in fields related to triple-negative breast cancer, hepatocellular carcinoma and so on.

HY-W440935

Stearic acid-PEG3400-Rhodamine
Stearic acid-PEG3400-Rhodamine is a fatty acid containing PEG polymer which can self assemble in an aqueous solution to form micelles. The polymer can be used to prepare nanoparticles for drug encapsulation. The red dye rhodamine can be easily traced by fluorescence microscopy. Rhodamine has maximum absorption at 570 nm and emission around 595 nm.

HY-185284

MeDZ lipid
MeDZ lipid is a zwitterion-type ionizable endosomal membrane destabilizer and anti-inflammatory agent that promotes endosomal escape. When incorporated into LNP formulations, MeDZ lipid enhances mRNA expression in lymph node antigen-presenting cells and promotes cytotoxic T cell activation. MeDZ lipid is compatible with existing targeted nanoparticle formulations to improve mRNA delivery efficiency.

HY-132289

Lipid M
Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability.

HY-182988

L-Arg-DSPE
L-Arg-DSPE is an arginine-functionalized DSPE lipid containing free guanidine groups. L-Arg-DSPE serves as a component of NO-responsive degradable drug-loaded liposomal nanomotors (L-Arg@Lip-DOX), promoting drug deep tumor tissue penetration and cellular internalization. L-Arg-DSPE can be used for the research of drug delivery.

HY-149664

3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol
3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol, a lipid, has been investigated in cancer gene therapy and vaccine delivery system.

HY-W440912

DSPE-PEG3400-Cy5
DSPE-PEG3400-Cy5 is a PEG phospholipid with Cy5 dye used in protein/nucelic acid labeling and fluorescence microscopy. The polymer can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-160270

DSPE-PEG5000-Fluor 488
DSPE-PEG5000-Fluor 488 is a PEG-dye-lipid conjugate consists of a DSPE phospholipid which is an unsaturated phospholipid, a Fluor 488 dye which is a cyanine dye that is prominently used in fluorescence microscopy with excitation and emission maxima at 499 nm and 520 nm and a large PEG spacer which links the former substance together.

HY-145539A

1,2-Dipalmitoyl-sn-glycero-3-PS
1,2-Dipalmitoyl-sn-glycero-3-PS is a phosphatidylserine phospholipid. 1,2-Dipalmitoyl-sn-glycero-3-PS is used for the preparation of phospholipid bilayers.

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