2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. α-MSH

α-MSH  (Synonyms: α-Melanocyte-Stimulating Hormone)

Cat. No.: HY-P0252 Purity: 99.98%
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SDS
Handling Instructions Technical Support

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 581-05-5

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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of α-MSH:

α-MSH Related Antibodies

Top Publications Citing Use of Products

    α-MSH purchased from MedChemExpress. Usage Cited in: Colloids Surf B Biointerfaces. 2025 Jul 24:255:114979.  [Abstract]

    α-MSH (0.3 μmol/L; 72 h). Effects of PT8 on the expression of cAMP signaling pathway-related factors in B16 cells. Relative quantification of MITF mRNA levels through quantitative PCR after treatment with PT8.

    α-MSH purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 May 15:470:134112.  [Abstract]

    α-MSH (0.1  μM; 48  h). Number of B16-F10 cells. Positive group: α-MSH.

    α-MSH purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 15;14(1):5740.  [Abstract]

    Western blotting of the indicated proteins in B16F10-dCas9 cells transduced with NTC sgRNA or Mc1r sgRNA. Cells were untreated or treated with 1  µM α-MSH (1  µM; 1  h) for 1  h. A representative result is shown from two independent experiments.

    α-MSH purchased from MedChemExpress. Usage Cited in: Blood Adv. 2023 Jul 11;7(13):3199-3212.  [Abstract]

    α-MSH (1 mg/kg; i.p.; once a day for a total of 7 days). Cell cycle analysis of LT-HSCs from the BM of WT mice treated with saline or α-MSH along with vehicle, MK-2206, or PD325901 (n = 6).

    α-MSH purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Sep 10;12(1):501.  [Abstract]

    α-MSH (200 nM; 48 h). The effects of hAMSC-CM or hAESC-CM on tyrosinase enzyme activity are confirmed by treatment with L-DOPA and detection of tyrosinase at 475 nm.

    View All Melanocortin Receptor Isoform Specific Products:

    View All Isoforms
    MC1R MC3R MC2R MC4R MC5R

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2].

    IC50 & Target

    MC4R

     

    In Vitro

    α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    α-MSH Related Antibodies
    In Vivo

    α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: IL-10–deficient mice[3]
    Dosage: 50 µg/0.2 ml saline
    Administration: I.p.
    Result: Given systemically effectively modulated inflammatory reactions.
    Molecular Weight

    1664.88

    Formula

    C77H109N21O19S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
    Sequence Shortening

    Ac-SYSMEHFRWGKPV-NH2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light, under nitrogen

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (60.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 12.5 mg/mL (7.51 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6006 mL 3.0032 mL 6.0064 mL
    5 mM 0.1201 mL 0.6006 mL 1.2013 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.98%

    SDS (252 KB)

    COA (251 KB) RP-HPLC (290 KB) MS (205 KB) Elemental Analysis Report (110 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.6006 mL 3.0032 mL 6.0064 mL 15.0161 mL
    5 mM 0.1201 mL 0.6006 mL 1.2013 mL 3.0032 mL
    DMSO 10 mM 0.0601 mL 0.3003 mL 0.6006 mL 1.5016 mL
    15 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0011 mL
    20 mM 0.0300 mL 0.1502 mL 0.3003 mL 0.7508 mL
    25 mM 0.0240 mL 0.1201 mL 0.2403 mL 0.6006 mL
    30 mM 0.0200 mL 0.1001 mL 0.2002 mL 0.5005 mL
    40 mM 0.0150 mL 0.0751 mL 0.1502 mL 0.3754 mL
    50 mM 0.0120 mL 0.0601 mL 0.1201 mL 0.3003 mL
    60 mM 0.0100 mL 0.0501 mL 0.1001 mL 0.2503 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    α-MSH Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    α-MSH581-05-5α-Melanocyte-Stimulating HormoneMelanocortin ReceptorMC Receptoralpha-melanocyte-stimulatinghormoneendogenousanti-inflammatoryneuroimmunomodulatorypeptideinflammationInhibitorinhibitorinhibit

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