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Cat. No.: HY-16990R

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Ac-YVAD-cmk (Standard)

Name: Ac-YVAD-cmk (Standard)
Brand: MedChemExpress
SKU: HY-16990R
Availability: PreOrder

(Synonyms: Caspase-1 Inhibitor II (Standard))

Ac-YVAD-cmk (Standard) is the analytical standard of Ac-YVAD-cmk (HY-16990). This product is intended for research and analytical applications. Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.

For research use only. We do not sell to patients.

CAS No.: 178603-78-6
Formula: C₂₄H₃₃ClN₄O₈
Molecular Weight:540.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ac-YVAD-cmk (Standard) Chemical Structure

CAS No.: 178603-78-6

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 178603-78-6
Molecular Weight 540.99
Formula C₂₄H₃₃ClN₄O₈
SMILES

OC1=CC=C(C[C@H](NC(C)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)C(C)C)=O)C=C1
Synonyms

Caspase-1 Inhibitor II (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13. [Content Brief]

[2]. Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771. [Content Brief]

[3]. Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131(3):383-386. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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