Aceanthrenequinone
Aceanthrenequinone is a polycyclic aromatic hydrocarbon quinone organic compound that belongs to the category of free radical photoinitiators. Aceanthrenequinone serves as an intermediate for dyes and pigments, and also acts as a substrate for organic synthesis and polymer materials. Aceanthrenequinone activates the Aryl Hydrocarbon Receptor pathway, induces the expression of CYP1A protein in the vascular system of zebrafish embryos, and causes the death of embryos at 120 hpf. Aceanthrenequinone is applicable to research related to industrial or biomedical applications.
For research use only. We do not sell to patients.
- CAS No.: 6373-11-1
- Formula: C16H8O2
- Molecular Weight:232.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP1A1 |
Aceanthrenequinone (5-100 μM; 24 h non-irradiation or 5 min irradiation + 24 h incubation) induces dose-dependent apoptosis in HEK293T cells, with increased apoptotic cell percentages at higher concentrations under both non-irradiation and 455 nm blue light irradiation conditions, and causes far less necrosis than BAPO[2].
Aceanthrenequinone (5-100 μM; 24 h non-irradiation) exhibits low cytotoxicity under non-irradiation conditions, with 82.0% relative cell survival at 100 μM after 24 h, causing only slight growth inhibition in HEK293T, LO-2, and BMSCs, and no inhibition in HUVEC-12 cells[2].
Aceanthrenequinone (5-100 μM; 5 min irradiation + 24 h incubation) cytotoxicity is slightly increased under 455 nm blue light irradiation, with 76.6% and 68.2% relative cell survival at 50 μM and 100 μM respectively after 24 h, but remains much lower than the cytotoxicity of BAPO across HEK293T, HUVEC-12, LO-2, and BMSC cell types[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T, HUVEC-12, LO-2, mouse bone marrow stromal cells (BMSCs)
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Concentration:5, 10, 25, 50, 100 μM
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Incubation Time:24 h (non-irradiation conditions)
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Result:Caused slight growth inhibition in HEK293T, LO-2, and BMSCs (but not HUVEC-12) in a concentration-dependent manner.
Maintained 82.0% relative cell survival rate across tested cell types at 100 μM, which was far higher than the survival rate observed with BAPO at the same concentration.
Made HEK293T cells the most sensitive to AATQ.
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Cell Line:HEK293T, HUVEC-12, LO-2, mouse bone marrow stromal cells (BMSCs)
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Concentration:5, 10, 25, 50, 100 μM
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Incubation Time:5 min (455 nm blue light irradiation) followed by 24 h incubation
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Result:Increased cytotoxicity relative to non-irradiation conditions, with significant effects observed at 50 and 100 μM.
Resulted in 76.6% relative cell survival at 50 μM and 68.2% relative cell survival at 100 μM.
Showed cytotoxicity substantially lower than that of BAPO under the same irradiation conditions.
Made HEK293T cells remain the most sensitive to AATQ.
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Cell Line:HEK293T cells
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Concentration:5, 10, 25, 50, 100 μM
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Incubation Time:24 h (non-irradiation conditions); 5 min (455 nm blue light irradiation) followed by 24 h incubation
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Result:Slightly increased apoptotic cell numbers at 5 and 10 μM under non-irradiation conditions.
Reached 20.0% late apoptotic/necrotic cells (Q2) and 19.1% early apoptotic cells (Q3) at 100 μM under non-irradiation conditions.
Induced a similar pattern of cell death under irradiation conditions, with apoptotic cell percentages increasing with concentration.
Caused far less necrosis than that induced by BAPO under irradiation conditions.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild type 5D strain (ahr2+)[1]
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Dosage:0.8 μM, 4 μM, 20 μM, 100 μM, 500 μM
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Administration:static immersion; 6-120 hpf
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Result:Induced a broad range of malformations including swim bladder, caudal and pectoral fin, somite, body axis, yolk sac edema, pericardial edema, eye, otic, brain, jaw, snout, and touch response malformations, as well as 120 hpf mortality, with higher EC50 values relative to the most acutely toxic OPAHs.
Induced CYP1A protein expression in the vasculature of exposed embryos.
Chemical Information
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CAS No. 6373-11-1
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Molecular Weight 232.23
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Formula C16H8O2
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SMILES
O=C1C(C2=C3C1=CC=CC3=CC4=C2C=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aceanthrenequinone Related Classifications
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