Alkyne-GRWHPM-CONH-NH-CMK
Alkyne-GRWHPM-CONH-NH-CMK is a covalent Cathepsin S inhibitor (IC50=82 nM). Alkyne-GRWHPM-CONH-NH-CMK has an N-terminal alkyne handle for CuAAC functionalization that engages off-target protein disulfide isomerase PDIA1. Alkyne-GRWHPM-CONH-NH-CMK can be used for the research of autoimmune disorders.
For research use only. We do not sell to patients.
- Formula: C43H59ClN14O8S
- Molecular Weight:967.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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cathepsin S 82 nM (IC50) |
Alkyne-GRWHPM-CONH-NH-CMK (compound 13) (0-50 μM; 25 min) covalently engages the catalytic cysteine of recombinant wild-type human Cathepsin S, with no detectable binding to the active site Cathepsin SC25S[1].
Alkyne-GRWHPM-CONH-NH-CMK (0-50 μM; 0.5 h) potently and selectively labels PDIA1, PDIA3, and PDIA6 in Raw 264.7 cell lysates, with no detectable engagement of endogenous Cat S[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 967.54
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Formula C43H59ClN14O8S
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Sequence
{alkyne-C3-CO-NH}-Gly-Arg-Trp-His-Pro-Met-{CONH-NH-CMK}
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Sequence Shortening
{alkyne-C3-CO-NH}-GRWHPM-{CONH-NH-CMK}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Alkyne-GRWHPM-CONH-NH-CMK Related Classifications
HY-P11857 Related Classifications
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