2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Sirtuin MDM-2/p53
  4. Altissimacoumarin F

Altissimacoumarin F (Compound 4) is a terpenylated coumarin. Altissimacoumarin F can be isolated from the stem bark of Ailanthus altissima. Altissimacoumarin F enhances SIRT1 activity, decreases p53 transcriptional activity. Altissimacoumarin F can be used for the research of age-related disorders.

For research use only. We do not sell to patients.

Altissimacoumarin F

Altissimacoumarin F Chemical Structure

CAS No. : 1384897-64-6

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Altissimacoumarin F Related Antibodies

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Description

Altissimacoumarin F (Compound 4) is a terpenylated coumarin. Altissimacoumarin F can be isolated from the stem bark of Ailanthus altissima. Altissimacoumarin F enhances SIRT1 activity, decreases p53 transcriptional activity. Altissimacoumarin F can be used for the research of age-related disorders[1].

IC50 & Target[1]

SIRT1

 

In Vitro

Altissimacoumarin F (10 μM; 10 min) enhances in vitro SIRT1 deacetylation activity[1].
Altissimacoumarin F (5-20 μM; 12 h post-transfection treatment) dose-dependently decreases p53 transcriptional activity in SIRT1-expressing HEK293 cells[1].
Altissimacoumarin F (20 μM; 12 h) increases the intracellular NAD-to-NADH ratio in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Altissimacoumarin F Related Antibodies
Molecular Weight

390.43

Formula

C21H26O7
CAS No.
SMILES

O=C1OC2=C(OC)C(OC[C@H](O)[C@@H](C)[C@@H](O3)[C@@H]3/C=C(C)/C)=C(OC)C=C2C=C1
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Altissimacoumarin F Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Altissimacoumarin F1384897-64-6SirtuinMDM-2/p53age-related disordersHEK293Inhibitorinhibitorinhibit

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