Anti-Rat CD4 Antibody (OX-38)
Based on 1 Customer Validation
Anti-Rat CD4 Antibody (OX-38) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to rat CD4. Anti-Rat CD4 Antibody (OX-38) can deplete CD4+ cells. Anti-Rat CD4 Antibody (OX-38) can be used for the researches of immunology and infection, such as borna disease and transplantation.
For research use only. We do not sell to patients.
- Purity : 98.91%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Rat
IC50 & Target
CD4
In Vitro
The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Rat CD4 Antibody (OX-38) (0.4 mL, 3 days before organ transplantation) causes marked prolongation of liver and heart allografts in Lewis rats[2].
Anti-Rat CD4 Antibody (OX-38) (1 mg/rat, i.p., weekly for 8 weeks) increases infection susceptibility in pneumocystis-infected pneumonia rats models[3].
Anti-Rat CD4 Antibody (OX-38) (5 mg/kg, a single dose) induces unresporusiveness in DA recipienta of PVG grafts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Borna disease virus-infected encephalomyelitis rats models[1]
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Dosage:2 mg
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Administration:Intraperitoneally injection, at days -1, 1, 14 and 21 of infection
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Result:Completely inhibited encephalitis and borna disease.
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Animal Model:Pneumocystis-infected pneumonia rats models[3]
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Dosage:1 mg/rat
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Administration:Intraperitoneally injection, weekly for 8 weeks
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Result:Reduced CD4+ cells and increased CD8+ cells.
Showed more trophic form of pneumocystis.
Gene ID
Accession
P05540
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo CD4+ T cell depletion; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Rat CD4 Antibody (OX-38)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Stitz L, et al. Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats. J Virol. 1992 Jun;66(6):3316-23. [Content Brief]
[2]. Sumimoto R, et al. Studies on the participation of different T cell subsets in rat liver allograft rejection. Comparison of liver with heart graft. Transpl Int. 1992;5 Suppl 1:S636-8. [Content Brief]
[3]. Thullen TD, et al. New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies. Infect Immun. 2003 Nov;71(11):6292-7. [Content Brief]
[4]. Qi Z, et al. Single dose anti-CD4 monoclonal antibody for induction of tolerance to cardiac allograft in high- and low-responder rat strain combinations. Transpl Immunol. 1997 Sep;5(3):204-11. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Rat CD4 Antibody (OX-38) Related Classifications
HY-P990135 Related Classifications
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