CXCR3 Antibody (YA10050)
(Synonyms: CD183, CXCR3)CXCR3 Antibody (YA10050) is a Armenian Hamster-derived and non-conjugated IgG Monoclonal antibody, targeting to CD183.
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Host:
Armenian Hamster
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Isotype:
IgG
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Application:
ICC/IF, FC
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Reactivity :
Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:50-200 | 1:500-2000 |
Product Details
CXCR3 Antibody (YA10050) is a Armenian Hamster-derived and non-conjugated IgG Monoclonal antibody, targeting to CD183.
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Host Armenian Hamster
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Clonality Monoclonal
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Species ReactivityMouse
Purified recombinant protein of Mouse N-terminus of CXCR3
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CXCR3 is a Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Receptor for chemokine CCL21. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling[1][2].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expresses in lymphoid organs and Th1 cells. -
Isoforms & Post-Translational Modification
CXCR3 has an amino acid length of 367, molecular weight is 41018 Da.
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding. -
Subunit
Homomer.
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SwissProt ID
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Synonyms
CD183, CXCR3
Documentation
References
[1]. Jenh CH, et al. Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors. J Immunol. 1999 Apr 1;162(7):3765-9. [Content Brief]
[2]. Soto H, et al. The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8205-10. [Content Brief]
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