Cxcr3 - chemokine (C-X-C motif) receptor 3 Gene

Also Known as Cd183; Cmkar3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12766

About Cxcr3

Chromosome X: 100,775,141-100,777,875 reverse strand.GRCm39:CM001013.3

This gene has 1 transcript (splice variant), 289 orthologues, 25 paralogues and is associated with 17 phenotypes. Biased expression in spleen adult (RPKM 18.9), mammary gland adult (RPKM 1.3) and 11 other tissues.

Summary

This gene encodes a transmembrane protein that functions as a receptor for C-X-R chemokines. Signalling through this protein regulates a variety of biological processes, including inflammation, immunity, and would healing. This protein also plays a role in tumor growth and metastasis. [provided by RefSeq, May 2015]

Cxcr3 Products (1)

mRNA Protein Name
NM_009910.3 NP_034040.1 C-X-C chemokine receptor type 3

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
23620790 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19008373 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr3 Protein Structure

7tmA_CXCR3

7tmA_CXCR3: cd15180 (52 - 327)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (52 - 79)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (86 - 111)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (122 - 152)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (164 - 186)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (210 - 239)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (246 - 276)

7tmA_CXCR3

7tmA_CXCR3: cd15180 (295 - 320)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 3

  • IP-10 receptor

  • interferon-inducible protein 10 receptor

Cxcr3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810807 CXCR3 Antibody (YA10050) ICC/IF, FC Mouse

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0426A Olopatadine hydrochloride Inhibitor 99.83% Unkown

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15319 AMG 487 Inhibitor 99.89% Unkown
HY-13406 TAK-779 Antagonist 99.89% Unkown
HY-10017 SCH 546738 Antagonist 98.71% Unkown
HY-149055 ACT-777991 Antagonist 99.86% Unkown
HY-15320 NBI-74330 Antagonist 99.76% Unkown
HY-111149A PS372424 hydrochloride Agonist ≥98.0% Unkown
HY-15319B AMG 487 (S-enantiomer) Antagonist 99.94% Unkown
HY-128063 CXCR3 antagonist 1 Antagonist 98.6% Unkown
HY-165428 SCH-900875 Inhibitor 98.16% Unkown
HY-151096 ACT-660602 Antagonist 99.02% Unkown
HY-111149 PS372424 Agonist / Unkown
HY-N16578 Hypoglaucin A Antagonist / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990254 Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Inhibitor 99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcr3 NCBI NCBI:2833