Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)
Based on 1 Customer Validation
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is an anti-mouse CXCR3/CD183 IgG monoclonal antibody. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) weakens the immune response by reducing the infiltration of CD4+ and CD8+ T cells. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) significantly prolongs the survival time of heart or islet transplants in mice. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) can be used for researches on immunology and cancer such as pancreatic cancer.
For research use only. We do not sell to patients.
- Purity : 99%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
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mCXCR3 |
In Vitro
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (0.001-100 μg/mL, 1 h) effectively inhibits ligand binding (CXCL10 inhibited by 60%, CXCL11 inhibited by 41%) in BaF3 cells[1].
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (0-300 μg/mL, 1 h) significantly inhibits chemotaxis induced by CXCL10 (inhibition 61%) and CXCL11 (inhibition 67%) in ConA stimulated mouse spleen cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (500 μg, i.p., on day 14, 16, 18 and 20) reduces the number of T cells, B cells, and plasma cells in the lungs in female C57BL/6 mice injected with mRNA-LNP vaccines[2].
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (200 μg, i.p., twice a week, for 15 days) significantly reverses the inhibitory effect of Sin3B deficiency on tumor growth and reduces CD8+ T cell infiltration in male C57BL/6J wild-type mice bearing KPC1199 tumors[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (H2d) mice[1]
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Dosage:100, 200 and 500 μg
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Administration:Intraperitoneal injection (i.p.), once every other day, for 2 weeks
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Result:Significantly prolonged the survival time of the transplant to 16-18 days at a dose of 200 μg or 500 μg (compared to 6-7 days in the control group) for the heart transplantation model.
Extended the survival time of the pancreatic islet transplant from 12.5 days to 21 days.
Significantly reduced the infiltration of CD4+ and CD8+ T cells and protected the myocardial and vascular structures.
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Animal Model:mRNA-LNP vaccines injected female C57BL/6 mice (6-8 weeks)[2]
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Dosage:500 μg
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Administration:Intraperitoneal injection (i.p.), on day 14, 16, 18 and 20
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Result:Reduced the number of CD44+Tet+CD4+/CD8+ T cells, RBD+ B cells, and IgA+ plasma cells in the lungs.
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Animal Model:1×106 KPC1199 cells injected male C57BL/6J wild-type mice[3]
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Dosage:200 μg
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Administration:Intraperitoneal injection (i.p.), twice a week, for 15 days
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Result:Significant increased tumor size and tumor volume.
Significantly reduced CD8+ T cell infiltration.
Gene ID
Accession
O88410
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo CXCR3 neutralization; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Uppaluri R, et al. Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody. Transplantation. 2008 Jul 15;86(1):137-47. [Content Brief]
[2]. Kwon DI, et al. Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice. Nat Immunol. 2025 Jun;26(6):908-919. [Content Brief]
[3]. Zhang Z, et al. SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer. Adv Sci (Weinh). 2024 Nov;11(43):e2402244. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Related Classifications
HY-P990254 Related Classifications
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