Arachidonoyl-L-carnitine chloride
Arachidonoyl-L-carnitine (C20:4 Carnitine) chloride is an arachidonic acid-L-carnitine complex and also a substrate for β-oxidation. Arachidonoyl-L-carnitine chloride undergoes mitochondrial β-oxidation, a process that requires energy-dependent function provided by NADP+ transhydrogenase supplying NADPH for 2,4-enoyl-CoA reductase activity. Arachidonoyl-L-carnitine chloride shows reduced respiration under uncoupling conditions, and ATP partially restores its oxidation.
For research use only. We do not sell to patients.
- CAS No.: 2133455-98-6
- Formula: C27H46ClNO4
- Molecular Weight:484.11
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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L-Carnitine (GMP)Endogenous Metabolite
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Human Endogenous Metabolite |
In Vitro
Arachidonoyl-L-carnitine chloride (40 μM) β-oxidation by isolated control rat liver mitochondria is inhibited by uncoupling conditions, with respiration rates reduced by ~36% in malonate-containing medium and ~40% in malate-containing medium compared to ADP-coupled rates[1].
Arachidonoyl-L-carnitine chloride (40 μM) β-oxidation by isolated clofibrate-treated (0.2% w/w diet for 12 days) rat liver mitochondria is no longer inhibited by uncoupling conditions, with respiration rates similar to or slightly higher than ADP-coupled rates in both malonate- and malate-containing media[1].
Arachidonoyl-L-carnitine chloride (40 μM) uncoupler-inhibited β-oxidation by isolated control rat liver mitochondria is potently rescued by ATP, increasing respiration rates to 9 ng-atoms of O/min per mg of protein, which is more than double the rate achieved with ADP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2133455-98-6
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Appearance Liquid
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Molecular Weight 484.11
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Formula C27H46ClNO4
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@@H](C[N+](C)(C)C)CC(O)=O)=O.[Cl-]
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Synonyms
C20:4 Carnitine chloride; L-Arachidonoylcarnitine chloride; L-Carnitine arachidonoyl ester chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Solvent & Solubility
In Vitro:
Ethanol : 30 mg/mL (61.97 mM; Need ultrasonic and warming)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.0656 mL | 10.3282 mL | 20.6565 mL | 51.6412 mL |
| 5 mM | 0.4131 mL | 2.0656 mL | 4.1313 mL | 10.3282 mL | |
| 10 mM | 0.2066 mL | 1.0328 mL | 2.0656 mL | 5.1641 mL | |
| 15 mM | 0.1377 mL | 0.6885 mL | 1.3771 mL | 3.4427 mL | |
| 20 mM | 0.1033 mL | 0.5164 mL | 1.0328 mL | 2.5821 mL | |
| 25 mM | 0.0826 mL | 0.4131 mL | 0.8263 mL | 2.0656 mL | |
| 30 mM | 0.0689 mL | 0.3443 mL | 0.6885 mL | 1.7214 mL | |
| 40 mM | 0.0516 mL | 0.2582 mL | 0.5164 mL | 1.2910 mL | |
| 50 mM | 0.0413 mL | 0.2066 mL | 0.4131 mL | 1.0328 mL | |
| 60 mM | 0.0344 mL | 0.1721 mL | 0.3443 mL | 0.8607 mL |
Arachidonoyl-L-carnitine chloride Related Classifications
HY-158801 Related Classifications
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