Arachidonoyl-L-carnitine chloride
Arachidonoyl-L-carnitine (C20:4 Carnitine) chloride is an arachidonic acid-L-carnitine complex and also a substrate for β-oxidation. Arachidonoyl-L-carnitine chloride undergoes mitochondrial β-oxidation, a process that requires energy-dependent function provided by NADP+ transhydrogenase supplying NADPH for 2,4-enoyl-CoA reductase activity. Arachidonoyl-L-carnitine chloride shows reduced respiration under uncoupling conditions, and ATP partially restores its oxidation.
For research use only. We do not sell to patients.
- Purity: 99.64%
- CAS No.: 2133455-98-6
- Formula: C27H46ClNO4
- Molecular Weight:484.11
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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L-Carnitine (GMP)
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Arachidonoyl-L-carnitine chloride (40 μM) β-oxidation by isolated control rat liver mitochondria is inhibited by uncoupling conditions, with respiration rates reduced by ~36% in malonate-containing medium and ~40% in malate-containing medium compared to ADP-coupled rates[1].
Arachidonoyl-L-carnitine chloride (40 μM) β-oxidation by isolated clofibrate-treated (0.2% w/w diet for 12 days) rat liver mitochondria is no longer inhibited by uncoupling conditions, with respiration rates similar to or slightly higher than ADP-coupled rates in both malonate- and malate-containing media[1].
Arachidonoyl-L-carnitine chloride (40 μM) uncoupler-inhibited β-oxidation by isolated control rat liver mitochondria is potently rescued by ATP, increasing respiration rates to 9 ng-atoms of O/min per mg of protein, which is more than double the rate achieved with ADP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2133455-98-6
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Appearance Liquid
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Molecular Weight 484.11
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Formula C27H46ClNO4
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@@H](C[N+](C)(C)C)CC(O)=O)=O.[Cl-]
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Synonyms
C20:4 Carnitine chloride; L-Arachidonoylcarnitine chloride; L-Carnitine arachidonoyl ester chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Arachidonoyl-L-carnitine chloride Related Classifications
HY-158801 Related Classifications
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