Cladosporin
Based on 1 Customer Validation
Cladosporin is an antibiotic and an an antifungal metabolite that can be produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin exhibits inhibitory activity against various dermatophytes, plant pathogens, and bacteria. Cladosporin also exhibits antimalarial activity through inhibition of cytoplasmic lysine-tRNA synthetase of Plasmodium (PfKrs1).
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- Reinheit: 99.90%
- CAS. Nr.: 35818-31-6
- Formel: C16H20O5
- Molecular Weight:292.33
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Speicherung:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
24 μM
Compound: 2
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Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in NO production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by Greiss assay
Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in NO production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by Greiss assay
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[PMID: 26651366] |
| BV-2 | IC50 |
27 μM
Compound: 2
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Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in PGE2 production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by ELISA
Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in PGE2 production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by ELISA
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[PMID: 26651366] |
Cladosporin inhibits the spore germination of Penicillium and Aspergillus strains (at the concentrations of 20-40 µg/mL with an inhibition rate of >50%). Cladosporin inhibits the growth of dermatophytes and plants pathogens, including T. interdigitale, T. rubrum, T. tonsurans, M. canis, E. floccosum, R. solani and M. flavus with MICs of 40-75 µg/mL[1].
Cladosporin inhibits the blood red stage and liver stage parasite forms of P. falciparum with IC50s of 40-90 nM. Cladosporin exhibits mild cytotoxicity in human cells (such as HEp2 and HepG2 with CC50s >10 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 35818-31-6
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Appearance Solid
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Molecular Weight 292.33
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Formel C16H20O5
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Color White to off-white
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SMILES
O=C1C2=C(O)C=C(O)C=C2C[C@H](C[C@H]3CCC[C@H](C)O3)O1
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Structure Classification
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Initial Source
Cladosporium cladosporioides
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (85.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. P M Scott, et al. Cladosporin, a new antifungal metabolite from Cladosporium cladosporioides. J Antibiot (Tokyo). 1971 Nov;24(11):747-55. [Content Brief]
[2]. Hoepfner D, et al., Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe. 2012 Jun 14;11(6):654-63. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.4208 mL | 17.1040 mL | 34.2079 mL | 85.5198 mL |
| 5 mM | 0.6842 mL | 3.4208 mL | 6.8416 mL | 17.1040 mL | |
| 10 mM | 0.3421 mL | 1.7104 mL | 3.4208 mL | 8.5520 mL | |
| 15 mM | 0.2281 mL | 1.1403 mL | 2.2805 mL | 5.7013 mL | |
| 20 mM | 0.1710 mL | 0.8552 mL | 1.7104 mL | 4.2760 mL | |
| 25 mM | 0.1368 mL | 0.6842 mL | 1.3683 mL | 3.4208 mL | |
| 30 mM | 0.1140 mL | 0.5701 mL | 1.1403 mL | 2.8507 mL | |
| 40 mM | 0.0855 mL | 0.4276 mL | 0.8552 mL | 2.1380 mL | |
| 50 mM | 0.0684 mL | 0.3421 mL | 0.6842 mL | 1.7104 mL | |
| 60 mM | 0.0570 mL | 0.2851 mL | 0.5701 mL | 1.4253 mL | |
| 80 mM | 0.0428 mL | 0.2138 mL | 0.4276 mL | 1.0690 mL |
Cladosporin Related Classifications
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