NCBP2 - nuclear cap binding protein subunit 2 Gene

Also Known as CBC2; NIP1; CBP20; PIG55

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22916

About NCBP2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,935,406-196,942,528 (from NCBI)

This gene has 13 transcripts (splice variants), 230 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 25.7), thyroid (RPKM 22.3) and 25 other tissues.

Summary

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCBP2 Products (4)

mRNA Protein Name
NM_001042540.2 NP_001036005.1 nuclear cap-binding protein subunit 2 isoform 2
NM_001308036.2 NP_001294965.1 nuclear cap-binding protein subunit 2 isoform 3
NM_001410857.1 NP_001397786.1 nuclear cap-binding protein subunit 2 isoform 4
NM_007362.5 NP_031388.2 nuclear cap-binding protein subunit 2 isoform 1

NCBP2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (42 - 112)

  • 0
  • 100
  • 156 a.a.
Protein Preferred Names Protein Names

nuclear cap-binding protein subunit 2

  • 20 kDa nuclear cap-binding protein

NCBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NCBP2 P52298 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
NCBP2 P52298 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
NCBP2 P52298 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09073 NCBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NCBP2 MGD MGI:1915342
Felis catus NCBP2 VGNC VGNC:68424
Macaca mulatta NCBP2 VGNC VGNC:75139
Bos taurus NCBP2 VGNC VGNC:31908
Rattus norvegicus NCBP2 RGD RGD:1596188
Canis familiaris NCBP2 VGNC VGNC:43646
Others NCBP2 NCBI