Valproic acid sodium (2:1)

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Oct 14;23(1):670. [Abstract]

Customer Validation
Cell viability under treatment with different concentrations of VPA (0-40 mM; 24 h).

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Oct 14;23(1):670. [Abstract]

Customer Validation
Pregnant females received intraperitoneal injections of 600 mg/kg VPA or saline on gestational day 12.5. Immunohistochemical staining representative images and quantification of Iba1 and GFAP in hippocampal CA1, CA3, and DG regions.

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

Customer Validation
Schemes of generating Fsp1-Cre:R26R-loxp-tdTomato mice and drug treatment to induce in situ transdifferentiation. Fsp1-Cre mice were crossed with R26Rloxp-tdTomato mice in which the expression of tdTomato is prevented by a loxP-flanked STOP cassette. The F1 mice would have the red fluorescent protein tdTomato expressed specifically in the fibroblasts. CRFVPTM were given once a week for 6 weeks. Immunofluorescence staining of the cryosections of the hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with vehicle (b) or CRFVPTM (c) for 6 weeks. C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age.

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

Customer Validation
Whole-heart imaging with light-sheet fluorescence microscopy after tissue clearing of the hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with vehicle (a) or CRFVPTM (b). (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

Customer Validation
a Schemes of obtaining PDGFRα-DreER:R26R-rox-tdTomato mice and drug treatment to induce in situ cardiac reprogramming in PDGFRα-DreER:R26R-roxtdTomato mice. PDGFRα-DreER mice were mated with R26R-rox-tdTomato mice in which the expression of tdTomato is prevented by a roxflanked STOP cassette. The expression of tdTomato in fibroblasts was turned on by tamoxifen treatment. CRFVPTM were given once a week for 6 weeks. b Body weigh change of the mice after chemical treatment. Immunofluorescence staining of the cryosections of the hearts from PDGFRα-DreER:R26R-rox-tdTomato mice treated with vehicle (c) or CRFVPTM (d) for 6 weeks. (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. [Abstract]

Customer Validation
Immunofluorescence staining of α-actinin in cryosections of hearts from Fsp1-Cre:R26R-loxp-tdTomato mice treated with 7 C cocktail (CRFVPTM) or cocktails by removing 1 compound from 7 C (7C-X) for 6 weeks in vivo with Fsp1-Cre:R26R-loxp-tdTomato mice. (C: CHIR99021, 14 mg/kg; R: RepSox, 8.6 mg/kg; F: Forskolin, 61.6 mg/kg; V: VPA, 250 mg/kg; T: TTNPB, 1 mg/kg and M: Rolipram, 2.5 mg/kg; P: Parnate, 2.7 mg/kg, CRFTM by oral gavage and VP by intraperitoneal injection once a week for 6 weeks in mice at about 8 weeks of age).

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2023 Jul;30(7):1811-1828. [Abstract]

Customer Validation
Western blot analysis using indicated antibodies was performed. Lysates were prepared from control (DMSO) cells or cells treated with Trichostatin A (TSA, 5 μM), Valproic acid (VPA, 0.5 mM), or RGFP966 (10 μM) for 24 h. GAPDH served as a loading control.

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Mar;42(3):470-481. [Abstract]

Customer Validation
Effects of Butyrate (But, 1 mM), Vpa (5 mM) and SAHA (Vor, 1 μM) on the expression of P-gp and BCRP, NF-кB p65 and phosphorylated p65 (p-p65), and IкBα and phosphorylated IкBα (p-IкBα).

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2020 Nov 1;7(1):52. [Abstract]

Customer Validation
Valproic acid (0.1 mmol/L; 0–14 days) was used. Representative microscopy images depicting the morphological changes after chemical induction were shown. Scale bars = 100 μm.

Valproic acid sodium (2:1) purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2020 Nov 1;7(1):52. [Abstract]

Customer Validation
Valproic acid (0.1 mmol/L; 0–7 days) was used. RT-qPCR analysis of mRNA expression levels of neuron-associated genes TUJ1 and MAP2, and DA neuron-associated genes TH and NURR1 was performed during the chemical induction.