2. Neuronal Signaling
  3. Beta-secretase
  4. BACE2-IN-1

BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes.

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BACE2-IN-1

BACE2-IN-1 Chemische Struktur

CAS. Nr. : 1676107-08-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
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BACE2-IN-1 Related Antibodies

Top Publications Citing Use of Products

Alle Beta-secretase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
BACE1 BACE2

  • Biologische Aktivität

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Beschreibung

BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes[1].

IC50 & Target

BACE2

1.6 nM (Ki)

BACE1

815.1 nM (Ki)

In Vitro

BACE2-IN-1 (compound 3l) inhibits BACE2 with an Ki value of 1.6 nM, 500 fold over BACE1 (Ki = 815.1 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BACE2-IN-1 Related Antibodies
Molekulargewicht

617.70

Formel

C36H38F3N3O3
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C)=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNCC3=CC=CC(C(F)(F)F)=C3)=O)=C1)N(C)[C@@H](C4=CC=CC=C4)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 62 mg/mL (100.37 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6189 mL 8.0945 mL 16.1891 mL
5 mM 0.3238 mL 1.6189 mL 3.2378 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.4%

SDS (251 KB)

COA (245 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6189 mL 8.0945 mL 16.1891 mL 40.4727 mL
5 mM 0.3238 mL 1.6189 mL 3.2378 mL 8.0945 mL
10 mM 0.1619 mL 0.8095 mL 1.6189 mL 4.0473 mL
15 mM 0.1079 mL 0.5396 mL 1.0793 mL 2.6982 mL
20 mM 0.0809 mL 0.4047 mL 0.8095 mL 2.0236 mL
25 mM 0.0648 mL 0.3238 mL 0.6476 mL 1.6189 mL
30 mM 0.0540 mL 0.2698 mL 0.5396 mL 1.3491 mL
40 mM 0.0405 mL 0.2024 mL 0.4047 mL 1.0118 mL
50 mM 0.0324 mL 0.1619 mL 0.3238 mL 0.8095 mL
60 mM 0.0270 mL 0.1349 mL 0.2698 mL 0.6745 mL
80 mM 0.0202 mL 0.1012 mL 0.2024 mL 0.5059 mL
100 mM 0.0162 mL 0.0809 mL 0.1619 mL 0.4047 mL
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BACE2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BACE2-IN-11676107-08-6Beta-secretaseBACEβ-Secretaseβ-secretase 2Tmem27type 2 diabetesstructure-based designbeta-site amyloid precursor protein cleaving enzyme 2non-peptideInhibitorinhibitorinhibit

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