Adenosine deaminase 2
Definition:
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.
References:
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[1]. Anton V Zavialov, et al. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. [Content Brief]
[2]. Andrey V Zavialov, et al. Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. J Leukoc Biol. 2010 Aug;88(2):279-90. [Content Brief]
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