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CEM-VLB

Definition:

CEM-VLB is a human T-cell-derived cancer cell line derived from Peripheral blood and associated with Childhood T acute lymphoblastic leukemia and Precursor T-cell acute lymphoblastic leukemia. CEM-VLB is a resistant derivative of CCRF-CEM selected against Vincaleukoblastine (Vinblastine. CEM-VLB is used as an in vitro model of Childhood T acute lymphoblastic leukemia and Precursor T-cell acute lymphoblastic leukemia to investigate tumor-cell growth, cell survival, and pharmacological response.

References:

[1]. Struski S, et al. Cytogenetic characterization of chromosomal rearrangement in a human vinblastine-resistant CEM cell line: use of comparative genomic hybridization and fluorescence in situ hybridization. Cancer genetics and cytogenetics. 2002;132(1):51-4.

[2]. Soudon J, et al. In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells-reversal of multidrug resistance by sera from phase I-treated patients. Cancer chemotherapy and pharmacology. 1995;36(3):195-203. [Content Brief]

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