Ceramide synthase 5

Definition:

Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia (By similarity).

References:

[1]. Hyun Joon Kim, et al. A fluorescent assay for ceramide synthase activity. J Lipid Res. 2012 Aug;53(8):1701-7. [Content Brief]

[2]. Rotem Tidhar, et al. Eleven residues determine the acyl chain specificity of ceramide synthases. J Biol Chem. 2018 Jun 22;293(25):9912-9921. [Content Brief]

[3]. Stefka Spassieva, et al. Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem. 2006 Nov 10;281(45):33931-8. [Content Brief]

[4]. Keisuke Jojima, et al. Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3. FASEB J. 2020 Feb;34(2):3318-3335. [Content Brief]

[5]. Takayuki Sassa, et al. Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. J Biol Chem. 2016 Apr 1;291(14):7477-87. [Content Brief]

[6]. Yukiko Mizutani, et al. 2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length. J Lipid Res. 2008 Nov;49(11):2356-64. [Content Brief]

[7]. Rotem Tidhar, et al. Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain. J Biol Chem. 2012 Jan 27;287(5):3197-206. [Content Brief]

[8]. Sarah Brice Russo, et al. Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. J Biol Chem. 2013 May 10;288(19):13397-409. [Content Brief]

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