CMRF35-like molecule 8

Definition:

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.

References:

[1]. Ido Bachelet, et al. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J Immunol. 2005 Dec 15;175(12):7989-95. [Content Brief]

[2]. B J Green, et al. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. Int Immunol. 1998 Jul;10(7):891-9. [Content Brief]

[3]. G J Clark, et al. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. Tissue Antigens. 2000 Feb;55(2):101-9. [Content Brief]

[4]. Eun-Ju Kim, et al. CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. Immunology. 2012 Mar;135(3):226-35. [Content Brief]

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