Forkhead box protein F2
Definition:
Probable transcription activator for a number of lung-specific genes. Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1.
References:
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[1]. M Hellqvist, et al. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. J Biol Chem. 1996 Feb 23;271(8):4482-90. [Content Brief]
[2]. Akira Higashimori, et al. Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis. Cancer Res. 2018 Apr 1;78(7):1643-1656. [Content Brief]
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