Integral membrane protein 2C
Definition:
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
References:
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[1]. Yanhua Gong, et al. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. BMB Rep. 2008 Apr 30;41(4):287-93. [Content Brief]
[2]. Shuji Matsuda, et al. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J Biol Chem. 2009 Jun 5;284(23):15815-25. [Content Brief]
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