Interleukin-17 receptor D

Definition:

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

References:

[1]. Satoru Torii, et al. Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell. 2004 Jul;7(1):33-44. [Content Brief]

[2]. Shiqin Xiong, et al. hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. J Biol Chem. 2003 Dec 12;278(50):50273-82. [Content Brief]

[3]. Ruey-Bing Yang, et al. A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling. J Biol Chem. 2003 Aug 29;278(35):33232-8. [Content Brief]

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