Sodium-coupled neutral amino acid symporter 1

Definition:

Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts. Also regulates synaptic plasticity.

References:

[1]. H Wang, et al. Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta. Biochem Biophys Res Commun. 2000 Jul 14;273(3):1175-9. [Content Brief]

[2]. M Desforges, et al. The contribution of SNAT1 to system A amino acid transporter activity in human placental trophoblast. Biochem Biophys Res Commun. 2010 Jul 16;398(1):130-4. [Content Brief]

[3]. D M Nelson, et al. Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts. Am J Physiol Cell Physiol. 2003 Feb;284(2):C310-5. [Content Brief]

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