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Trafficking protein particle complex subunit 14

Definition:

Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether. TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis. Modulates YAP1 activity as transcriptional regulator.

References:

[1]. Masataka Amisaki, et al. Identification of genes involved in the regulation of TERT in hepatocellular carcinoma. Cancer Sci. 2019 Feb;110(2):550-560. [Content Brief]

[2]. Yonatan Perez, et al. Mutations in the microtubule-associated protein MAP11 (C7orf43) cause microcephaly in humans and zebrafish. Brain. 2019 Mar 1;142(3):574-585. [Content Brief]

[3]. Adrian Cuenca, et al. The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis. J Biol Chem. 2019 Oct 18;294(42):15418-15434. [Content Brief]

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