Transmembrane protein 106A
Definition:
Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration.
References:
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[1]. Chenglong Wu, et al. TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer. Kidney Blood Press Res. 2017;42(5):853-864. [Content Brief]
[2]. Juncai Liu, et al. TMEM106A inhibits cell proliferation, migration, and induces apoptosis of lung cancer cells. J Cell Biochem. 2018 Nov 19. [Content Brief]
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