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U138-MG

Definition:

U138-MG is a human cancer cell line derived from Brain and associated with Astrocytoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. U138-MG is used as an in vitro model of Astrocytoma to investigate PI3K-AKT signaling, ERK signaling, cell proliferation, receptor signaling and trafficking, gene-expression regulation, and drug resistance.

References:

[1]. Jacques-Silva MC, et al. ERK, PKC and PI3K/Akt pathways mediate extracellular ATP and adenosine-induced proliferation of U138-MG human glioma cell line. Oncology. 2004;67(5-6):450-9.

[2]. Wolff D, et al. Reduced levels of IE2 gene expression and shutdown of early and late viral genes during latent infection of the glioblastoma cell line U138-MG with selectable recombinants of human cytomegalovirus. Virology. 1994;204(1):101-13.

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