Uridine phosphorylase 2
Definition:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Shows broad substrate specificity and accepts uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
References:
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[1]. Magnus Johansson, et al. Identification of a novel human uridine phosphorylase. Biochem Biophys Res Commun. 2003 Jul 18;307(1):41-6. [Content Brief]
[2]. Tarmo P Roosild, et al. A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity. J Struct Biol. 2011 Nov;176(2):229-37. [Content Brief]
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