1. Immunology/Inflammation
  2. STING
  3. cGAMP

cGAMP (Synonyms: Cyclic GMP-AMP; 3',3'-cGAMP)

製品番号: HY-12512 純度: 98.56%
取扱説明書

cGAMP (Cyclic GMP-AMP; 3',3'-cGAMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用としては使用しないように、十分ご注意ください。

cGAMP 構造式

cGAMP 構造式

CAS 番号 : 849214-04-6

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in Water USD 2448 在庫あり
Estimated Time of Arrival: December 31
500 μg USD 190 在庫あり
Estimated Time of Arrival: December 31
1 mg USD 330 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 1250 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 2150 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 3750 在庫あり
Estimated Time of Arrival: December 31
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

cGAMP (Cyclic GMP-AMP; 3',3'-cGAMP) is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA; STING ligand[1][2][3][4].

IC50 & Target

Endogenous Metabolite

体外実験

cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice[2].
cGAMP directly activates murine and human dendritic cells in vitro[2].
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4].

体内実験

cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

Animal Model: Female C57BL/6 (H-2b) mice 6–8 weeks old[2]
Dosage: 5 µg
Administration: Nostril mucosal adjuvant
Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
分子量

674.41

分子式

C₂₀H₂₄N₁₀O₁₃P₂

CAS 番号

849214-04-6

SMILES

O=P(O[[email protected]]1[[email protected]@H](O)[[email protected]](N2C=NC3=C2N=CN=C3N)O[[email protected]@H]1COP4(O)=O)(O)OC[[email protected]@H]5[[email protected]@H](O4)[[email protected]@H](O)[[email protected]](N6C=NC7=C6N=C(N)NC7=O)O5

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 20 mg/mL (29.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4828 mL 7.4139 mL 14.8278 mL
5 mM 0.2966 mL 1.4828 mL 2.9656 mL
10 mM 0.1483 mL 0.7414 mL 1.4828 mL
*Please refer to the solubility information to select the appropriate solvent.
参考文献

純度: 98.56%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • モル濃度カルキュレーター

  • 希釈カルキュレーター

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

cGAMPCyclic GMP-AMP3',3'-cGAMPSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSligand secondmessengerInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

 

タイトル

お名前 *

 

PC 用メールアドレス *

電話番号 *

 

勤務先/学校名 *

Department *

 

カスタマ需要量 *

国会或いは地域 *

     

必ず会社名を記載ください。個人への返信は行いません。

メッセージ

バルクお問い合わせ

Inquiry Information

製品名:
cGAMP
製品番号:
HY-12512
数量:
MCE 日本正規代理店: