Map3k4 - mitogen-activated protein kinase kinase kinase 4 Gene

Also Known as Tas; MTK1; RP17; Mek4b; Mekk4; Rp17a; MEKK 4; D17Rp17; MAPKKK4; D17Rp17e; mKIAA0213

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26407

Summary

Enables protein kinase activity. Involved in intracellular signal transduction and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and placenta development. Located in cytoplasm. Is expressed in several structures, including central nervous system; future brain; and genitourinary system. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map3k4 Products (2)

mRNA Protein Name
NM_001357722.1 NP_001344651.1 mitogen-activated protein kinase kinase kinase 4 isoform 2
NM_011948.2 NP_036078.2 mitogen-activated protein kinase kinase kinase 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12878610 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
16157600 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chorionic trophoblast cell differentiation IMP
IMP: Inferred from mutant phenotype
19289495 MGI
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
16157600 MGI
acts upstream of or within male germ-line sex determination IMP
IMP: Inferred from mutant phenotype
6855886 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
19289495 MGI
involved in positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
16157600 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
12878610 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19289495 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16157600 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 4

  • MAPK/ERK kinase kinase 4

  • MEK kinase 4

  • T-associated sex reversal

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08057 MAP3K4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19516 Map3k4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26011 Map3k4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k4 NCBI NCBI:4216