NAA10 - N-alpha-acetyltransferase 10, NatA catalytic subunit Gene

Also Known as TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8260

About NAA10

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,929,225-153,935,037 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 8 phenotypes. Ubiquitous expression in fat (RPKM 16.8), appendix (RPKM 16.4) and 25 other tissues.

Summary

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

NAA10 Products (3)

mRNA	Protein	Name
NM_001256119.2	NP_001243048.1	N-alpha-acetyltransferase 10 isoform 2
NM_001256120.2	NP_001243049.1	N-alpha-acetyltransferase 10 isoform 3
NM_003491.4	NP_003482.1	N-alpha-acetyltransferase 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to acetyltransferase activity	IDA IDA: Inferred from direct assay	15496142	GOA
contributes to peptide alpha-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	19480662	GOA
enables peptide alpha-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	25489052	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15496142	GOA
contributes to ribosome binding	IDA IDA: Inferred from direct assay	15496142	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-terminal protein amino acid acetylation	IDA IDA: Inferred from direct assay	15496142	GOA
involved in negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric	IDA IDA: Inferred from direct assay	27422821	GOA
involved in protein acetylation	IDA IDA: Inferred from direct assay	27708256	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NatA complex	IDA IDA: Inferred from direct assay	19480662	GOA
part of NatA complex	IPI IPI: Inferred from physical interaction	15496142	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15496142	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15496142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA10 Protein Structure

Acetyltransf_1

0
100
200
235 a.a.

Protein Preferred Names	Protein Names
N-alpha-acetyltransferase 10	ARD1 homolog A, N-acetyltransferase

NAA10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAA10	P41227	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	NAA10	P41227	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	NAA10	P41227	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	NAA10	P41227	EHMT2	Homo sapiens	A2ABF9	Y2H Array	25416956
Intra	NAA10	P41227	EHMT2	Homo sapiens	A2ABF9	Validated Y2H	25416956
Intra	NAA10	P41227	ZBTB14	Homo sapiens	O43829	Validated Y2H	25416956
Intra	NAA10	P41227	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	NAA10	P41227	ZBTB14	Homo sapiens	O43829	Y2H Array	32296183
Intra	NAA10	P41227	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	BCOR	Homo sapiens	Q6W2J9-4	Validated Y2H	25416956
Intra	NAA10	P41227	BCOR	Homo sapiens	Q6W2J9-4	Y2H Array	25416956
Intra	NAA10	P41227	NAA15	Homo sapiens	Q9BXJ9	Anti Bait CoIP	15496142
Intra	NAA10	P41227	NAA15	Homo sapiens	Q9BXJ9	Anti Bait CoIP	19480662
Intra	NAA10	P41227	NAA15	Homo sapiens	Q9BXJ9	IF	15496142
Intra	NAA10	P41227	NAA15	Homo sapiens	Q9BXJ9	Anti Tag CoIP	15496142
Intra	NAA10	P41227	NAA15	Homo sapiens	Q9BXJ9	Anti Tag CoIP	33961781
Intra	NAA10	P41227	CREBRF	Homo sapiens	Q8IUR6	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	CREBRF	Homo sapiens	Q8IUR6	Validated Y2H	32296183
Intra	NAA10	P41227	CREBRF	Homo sapiens	Q8IUR6	Y2H Array	32296183
Intra	NAA10	P41227	DHX57	Homo sapiens	Q6P158	Validated Y2H	32296183
Intra	NAA10	P41227	NAA50	Homo sapiens	Q9GZZ1	Anti Tag CoIP	33961781
Intra	NAA10	P41227	NAA50	Homo sapiens	Q9GZZ1	Anti Bait CoIP	16507339
Intra	NAA10	P41227	NAA50	Homo sapiens	Q9GZZ1	Anti Bait CoIP	19480662
Intra	NAA10	P41227	SEMA3B	Homo sapiens	Q13214-2	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	SEMA3B	Homo sapiens	Q13214-2	Validated Y2H	32296183
Intra	NAA10	P41227	SEMA3B	Homo sapiens	Q13214-2	Y2H Array	32296183
Intra	NAA10	P41227	PDE4DIP	Homo sapiens	Q5VU43	Validated Y2H	25416956
Intra	NAA10	P41227	PDE4DIP	Homo sapiens	Q5VU43	Anti Tag CoIP	33961781
Intra	NAA10	P41227	ACOT12	Homo sapiens	Q8WYK0	Validated Y2H	32296183
Intra	NAA10	P41227	ACOT12	Homo sapiens	Q8WYK0	Y2H Array	32296183
Intra	NAA10	P41227	ACOT12	Homo sapiens	Q8WYK0	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	GPATCH2L	Homo sapiens	Q9NWQ4-1	Y2H Array	32296183
Intra	NAA10	P41227	GPATCH2L	Homo sapiens	Q9NWQ4-1	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	NAA10	P41227	RAB3IP	Homo sapiens	Q96QF0-7	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	RAB3IP	Homo sapiens	Q96QF0-7	Validated Y2H	32296183
Intra	NAA10	P41227	RAB3IP	Homo sapiens	Q96QF0-7	Y2H Array	32296183
Intra	NAA10	P41227	KRTAP10-6	Homo sapiens	P60371	Validated Y2H	32296183
Intra	NAA10	P41227	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	NAA10	P41227	NOXA1	Homo sapiens	Q86UR1-2	MAPPIT	32296183
Intra	NAA10	P41227	NOXA1	Homo sapiens	Q86UR1-2	Validated Y2H	32296183
Intra	NAA10	P41227	BAALC	Homo sapiens	Q8WXS3-2	Y2H Array	32296183
Intra	NAA10	P41227	BAALC	Homo sapiens	Q8WXS3-2	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	BAALC	Homo sapiens	Q8WXS3-2	Validated Y2H	32296183
Intra	NAA10	P41227	ARHGEF6	Homo sapiens	Q15052	Anti Tag CoIP	21295525
Intra	NAA10	P41227	ARHGEF6	Homo sapiens	Q15052	Pull Down	21295525
Intra	NAA10	P41227	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	NAA10	P41227	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	NAA10	P41227	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	NFE2L2	Homo sapiens	Q16236	Acetylase Assay	36442525
Intra	NAA10	P41227	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	NAA10	P41227	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	NAA10	P41227	RBCK1	Homo sapiens	Q9BYM8	Validated Y2H	25416956
Intra	NAA10	P41227	MRPS11	Homo sapiens	P82912	Validated Y2H	32296183
Intra	NAA10	P41227	MRPS11	Homo sapiens	P82912	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	PPP2R3B	Homo sapiens	Q9Y5P8	Y2H Array	32296183
Intra	NAA10	P41227	PPP2R3B	Homo sapiens	Q9Y5P8	Validated Y2H	32296183
Intra	NAA10	P41227	PPP2R3B	Homo sapiens	Q9Y5P8	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	SNX33	Homo sapiens	Q8WV41	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	SNX33	Homo sapiens	Q8WV41	Validated Y2H	32296183
Intra	NAA10	P41227	SNX33	Homo sapiens	Q8WV41	Y2H Array	32296183
Intra	NAA10	P41227	TSEN54	Homo sapiens	Q7Z6J9	Validated Y2H	32296183
Intra	NAA10	P41227	NAA16	Homo sapiens	Q6N069	Anti Tag CoIP	33961781
Intra	NAA10	P41227	NAA16	Homo sapiens	Q6N069	Anti Tag CoIP	19480662
Intra	NAA10	P41227	NAA16	Homo sapiens	Q6N069	Anti Bait CoIP	19480662
Intra	NAA10	P41227	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	NAA10	P41227	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	NAA10	P41227	MKRN1	Homo sapiens	Q9UHC7	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	MKRN1	Homo sapiens	Q9UHC7	Validated Y2H	32296183
Intra	NAA10	P41227	MKRN1	Homo sapiens	Q9UHC7	Y2H Array	32296183
Intra	NAA10	P41227	MDM4	Homo sapiens	O15151	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	MDM4	Homo sapiens	O15151	Y2H Array	32296183
Intra	NAA10	P41227	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	NAA10	P41227	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	NAA10	P41227	TAF7L	Homo sapiens	Q5H9L4	Validated Y2H	32296183
Intra	NAA10	P41227	TAF7L	Homo sapiens	Q5H9L4	Y2H Array	32296183
Intra	NAA10	P41227	TAF7L	Homo sapiens	Q5H9L4	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	CCDC106	Homo sapiens	Q9BWC9	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	CCDC106	Homo sapiens	Q9BWC9	Validated Y2H	32296183
Intra	NAA10	P41227	CCDC106	Homo sapiens	Q9BWC9	Y2H Array	32296183
Intra	NAA10	P41227	ARHGEF7	Homo sapiens	Q14155	Anti Bait CoIP	21295525
Intra	NAA10	P41227	CDCA5	Homo sapiens	Q96FF9	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	CDCA5	Homo sapiens	Q96FF9	Validated Y2H	32296183
Intra	NAA10	P41227	CDCA5	Homo sapiens	Q96FF9	Y2H Array	32296183
Intra	NAA10	P41227	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	32296183
Intra	NAA10	P41227	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	NAA10	P41227	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	CALCOCO2	Homo sapiens	Q13137	Y2H Array	32296183
Intra	NAA10	P41227	CALCOCO2	Homo sapiens	Q13137	Y2H Array	31515488
Intra	NAA10	P41227	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	NAA10	P41227	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	NAA10	P41227	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	25416956
Intra	NAA10	P41227	CEP44	Homo sapiens	Q9C0F1	Y2H Array	25416956
Intra	NAA10	P41227	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	25416956
Intra	NAA10	P41227	RCN3	Homo sapiens	Q96D15	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	RCN3	Homo sapiens	Q96D15	Validated Y2H	32296183
Intra	NAA10	P41227	RCN3	Homo sapiens	Q96D15	Y2H Array	32296183
Intra	NAA10	P41227	CCDC174	Homo sapiens	Q6PII3	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	CCDC174	Homo sapiens	Q6PII3	Validated Y2H	32296183
Intra	NAA10	P41227	CCDC174	Homo sapiens	Q6PII3	Y2H Array	32296183
Intra	NAA10	P41227	RAB3IP	Homo sapiens	Q96QF0	Y2H Array	25416956
Intra	NAA10	P41227	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	NAA10	P41227	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	NAA10	P41227	PLSCR3	Homo sapiens	Q9NRY6	Validated Y2H	32296183
Intra	NAA10	P41227	PLSCR3	Homo sapiens	Q9NRY6	Y2H Array	32296183
Intra	NAA10	P41227	PLSCR3	Homo sapiens	Q9NRY6	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	ZNF202	Homo sapiens	O95125	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	ZNF202	Homo sapiens	O95125	Y2H Array	32296183
Intra	NAA10	P41227	KIFAP3	Homo sapiens	Q92845	Y2H Array	32296183
Intra	NAA10	P41227	KIFAP3	Homo sapiens	Q92845	Y2H Prey Pooling	32296183
Intra	NAA10	P41227	KIFAP3	Homo sapiens	Q92845	Y2H Array	31515488
Intra	NAA10	P41227	KIFAP3	Homo sapiens	Q92845	Validated Y2H	32296183
Intra	NAA10	P41227	PDE4DIP	Homo sapiens	Q5VU43-2	Validated Y2H	32296183
Intra	NAA10	P41227	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Array	32296183
Intra	NAA10	P41227	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NAA10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77096	NAA10/ARD1 Protein, Human (sf9)	P41227 (M1-S235)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77097	NAA10/ARD1 Protein, Human (sf9, His-GST)	P41227 (M1-S235)	≥ 95%, as determined by reducing SDS-PAGE.

NAA10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84306	NAA10 Antibody (YA4003)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P84306A	NAA10 Antibody (YA4003)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey

Related Diseases

Diseases	Alias
Ogden Syndrome	OGDNS N-Terminal Acetyltransferase Deficiency NATD N-Alpha-Acetyltransferase X-Linked Malformation And Infantile Lethality Syndrome Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Microphthalmia, Syndromic 1	MCOPS1 Lenz Microphthalmia Syndrome Lenz Dysplasia Mcops4 Syndromic Microphthalmia 1 Lenz Microphthalmia Maa Microphthalmia Or Anophthalmos With Associated Anomalies Syndromic Microphthalmia Type 4 Microphthalmia, Syndromic 4 Microphthalmia, Syndromic 4, Formerly Mcops4, Formerly Anop1, Formerly Maa, Formerly Lenz Type Microphthalmia Syndromic Microphthalmia 4 Microphthalmia Lenz Type Microphthalmia Syndromic 1 Syndromic Microphthalmia Type 1 Microphthalmia Syndromic 4 Microphthalmia With Ankyloblepharon And Intellectual Disability Microphthalmia, Lenz Type Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome Microphthalmia, Syndromic, 1 Anop1 Microphthalmia, Syndromic, Type 1
Cardiogenic Shock	Shock Cardiogenic Shock, Cardiogenic
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Microphthalmia, Syndromic 13	X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome MCOPS13 Maine Microphthalmos Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation Syndromic Microphthalmia 13 X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome Microphthalmia, Syndromic, 13 Microphthalmia, Syndromic, Type 13
Syndromic Microphthalmia	Microphthalmia, Syndromic
Epilepsy, Familial Temporal Lobe, 6	ETL6 Familial Temporal Lobe Epilepsy 6
Microcephaly And Chorioretinopathy 2
Developmental Coordination Disorder	Motor Skills Disorders
Autosomal Dominant Severe Congenital Neutropenia	Severe Congenital Neutropenia Autosomal Dominant Neutropenia, Congenital, Severe, Autosomal Dominant
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156140	Naa50-IN-1	Inhibitor	99.94%	Unkown
HY-RS08985	NAA10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17987	Naa10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24458	Naa10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NAA10	VGNC	VGNC:106831
Felis catus	NAA10	VGNC	VGNC:96704
Canis familiaris	NAA10	VGNC	VGNC:54174
Mus musculus	NAA10	MGD	MGI:1915255
Macaca mulatta	NAA10	VGNC	VGNC:107112
Rattus norvegicus	NAA10	RGD	RGD:1565315
Others	NAA10	NCBI