CDCA5 - cell division cycle associated 5 Gene

Also Known as SORORIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 113130

About CDCA5

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,061,093-65,084,040 (from NCBI)

This gene has 10 transcripts (splice variants) and 170 orthologues. Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues.

Summary

Predicted to enable chromatin binding activity. Involved in double-strand break repair; mitotic sister chromatid segregation; and regulation of cell cycle process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CDCA5 Products (1)

mRNA	Protein	Name
NM_080668.4	NP_542399.1	sororin

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21111234	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15837422	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	17349791	GOA
involved in mitotic cell cycle	IDA IDA: Inferred from direct assay	15837422	GOA
involved in mitotic chromosome condensation	IMP IMP: Inferred from mutant phenotype	15837422	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	15837422	GOA
involved in mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	17349791	GOA
involved in mitotic sister chromatid cohesion	IPI IPI: Inferred from physical interaction	21111234	GOA
involved in positive regulation of exit from mitosis	IMP IMP: Inferred from mutant phenotype	23548868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA5 Protein Structure

Sororin

0
100
200
252 a.a.

Protein Preferred Names	Protein Names
sororin	cell division cycle-associated protein 5

CDCA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDCA5	Q96FF9	PDS5A	Homo sapiens	Q29RF7	Anti Bait CoIP	21111234
Intra	CDCA5	Q96FF9	PDS5A	Homo sapiens	Q29RF7	Anti Tag CoIP	26496610
Intra	CDCA5	Q96FF9	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	CDCA5	Q96FF9	NAA10	Homo sapiens	P41227	Anti Tag CoIP	33961781
Intra	CDCA5	Q96FF9	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	33961781
Intra	CDCA5	Q96FF9	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

CDCA5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82864	CDCA5 Antibody (YA2609)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Roberts-Sc Phocomelia Syndrome	Roberts Syndrome Sc Phocomelia Syndrome RBS Long Bone Deficiencies Associated With Cleft Lip-Palate Sc Pseudothalidomide Syndrome Appelt-Gerken-Lenz Syndrome Pseudothalidomide Syndrome Tetraphocomelia-Cleft Palate Syndrome Hypomelia Hypotrichosis Facial Hemangioma Syndrome Roberts Syndrome/Sc Phocomelia Roberts Tetraphocomelia Syndrome Sc Syndrome Sc Phocomelia Sc Disease Sc Hemoglobin Sc Disease
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02314	CDCA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDCA5	VGNC	VGNC:39015
Felis catus	CDCA5	VGNC	VGNC:60667
Bos taurus	CDCA5	VGNC	VGNC:56261
Mus musculus	CDCA5	MGD	MGI:1915099
Rattus norvegicus	CDCA5	RGD	RGD:1560863
Macaca mulatta	CDCA5	VGNC	VGNC:100907
Others	CDCA5	NCBI