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Cat. No.: HY-113619

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ABT-255 free base

ABT-255 free base is an orally active anti-bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis.

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CAS No.: 186293-38-9
Formule: C₂₁H₂₄FN₃O₃
Masse moléculaire:385.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

ABT-255 free base Chemical Structure

CAS No.: 186293-38-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

In Vitro

ABT-255 (0.016-0.5 μg/mL) free base shows MIC values of 0.016 μg/mL against ATCC 35801, 0.031 μg/mL against ATCC 25618, and 0.031 μg/mL against both 35837b (Ethambutol (HY-B0535)-resistant) and 35838c (Rifampin (HY-B0272)-resistant)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ABT-255 (3.13-25 mg/kg, p.o., once daily, 4 weeks) free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

4- to 6-week-old female CF-1 mice were intraperitoneally injected with overnight cultures of Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli JUHL, with the inoculum adjusted to approximately 100 times the 50% lethal dose^[1]
Dosage:

3.13, 6.25, 12.5, 25 mg/kg
Administration:

p.o. once daily for 4 weeks
Result:

Reduced Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli in mice JUHL.

Animal Model:

4- to 6-week-old female CF-1 mice were intravenously injected via the caudal tail vein with approximately 10⁷ viable M. tuberculosis cells suspended in 0.2 mL of modified 7H10 broth^[1]
Dosage:

6.25, 12.5, 25 mg/kg
Administration:

p.o. once daily for 4 weeks
Result:

Produced a dose-responsive 0- to 5.5-log reduction in M. tuberculosis (ATCC 35801) counts in lung tissue.
Produced a dose-related 1- to 3-log reduction in viable Ethambutol (HY-B0535)-resistant M. tuberculosis (ATCC 35837) counts in lung tissue.
Produced a dose-responsive 1- to 2.5-log reduction in viable Rifampin (HY-B0272)-resistant Mycobacterium tuberculosis (ATCC 35838) counts in lung tissue.

Chemical Information

CAS No. 186293-38-9
Masse moléculaire 385.43
Formule C₂₁H₂₄FN₃O₃
SMILES

O=C(C1=CC(C2CC2)=C3C(C)=C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)C(F)=CN3C1=O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Oleksijew A, et al. In vivo efficacy of ABT-255 against drug-sensitive and -resistant Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Oct;42(10):2674-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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