Carvacrol methyl ether
Based on 1 Customer Validation
Carvacrol methyl ether is a carvacrol derivative isolated from plant essential oils. Carvacrol methyl ether essentially lost its antibacterial activity, exhibiting only a weak inhibitory effect on Saccharomyces cerevisiae at the highest tested concentration of 3 g/L.
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- Pureté : 99.89%
- CAS No.: 6379-73-3
- Formule: C11H16O
- Masse moléculaire:164.25
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Carvacrol methyl ether (0.1-3 g/L; 48 h) is ineffective at inhibiting growth of Pseudomonas fluorescens, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Lactobacillus plantarum at concentrations up to 3 g/L, and only inhibits Saccharomyces cerevisiae growth at 3 g/L in liquid phase broth assays[2].
Carvacrol methyl ether (2.5-30 mg per petri dish; 48 h (bacteria/yeast); 15 days (fungi)) is ineffective at inhibiting growth of Pseudomonas fluorescens, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Lactobacillus plantarum, Saccharomyces cerevisiae, and Botrytis cinerea at doses up to 30 mg per petri dish in vapour phase microatmosphere assays[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6379-73-3
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Appearance Liquid (Density: 0.936 g/cm3)
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Masse moléculaire 164.25
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Formule C11H16O
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Color Colorless to light yellow
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SMILES
CC(C1=CC=C(C)C(OC)=C1)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (608.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Ben Arfa A, et al. Antimicrobial activity of carvacrol related to its chemical structure. Lett Appl Microbiol. 2006;43(2):149-154. [Content Brief]
[3]. Mastelić J, et al. Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives. J Agric Food Chem. 2008;56(11):3989-3996. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0883 mL | 30.4414 mL | 60.8828 mL | 152.2070 mL |
| 5 mM | 1.2177 mL | 6.0883 mL | 12.1766 mL | 30.4414 mL | |
| 10 mM | 0.6088 mL | 3.0441 mL | 6.0883 mL | 15.2207 mL | |
| 15 mM | 0.4059 mL | 2.0294 mL | 4.0589 mL | 10.1471 mL | |
| 20 mM | 0.3044 mL | 1.5221 mL | 3.0441 mL | 7.6104 mL | |
| 25 mM | 0.2435 mL | 1.2177 mL | 2.4353 mL | 6.0883 mL | |
| 30 mM | 0.2029 mL | 1.0147 mL | 2.0294 mL | 5.0736 mL | |
| 40 mM | 0.1522 mL | 0.7610 mL | 1.5221 mL | 3.8052 mL | |
| 50 mM | 0.1218 mL | 0.6088 mL | 1.2177 mL | 3.0441 mL | |
| 60 mM | 0.1015 mL | 0.5074 mL | 1.0147 mL | 2.5368 mL | |
| 80 mM | 0.0761 mL | 0.3805 mL | 0.7610 mL | 1.9026 mL | |
| 100 mM | 0.0609 mL | 0.3044 mL | 0.6088 mL | 1.5221 mL |
Carvacrol methyl ether Related Classifications
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