CK147
CK147 is a Sec61α translocase inhibitor that blocks the co-translational translocation of proteins by binding to and inhibiting the Sec61 protein translocation channel on the endoplasmic reticulum membrane. CK147 exhibits potent CD4 downregulation activity with an IC50 of 0.04 µM. CK147 prevents HIV entry into host cells and shows significant cytotoxicity. CK147 can be used in studies related to HIV infection.
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- CAS No.: 1883356-12-4
- Formule: C32H48N4O4S2
- Masse moléculaire:616.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
CK147 (0.01-100 μM; 18 h) potently down-modulates human CD4 expression in transiently transfected HEK293T cells with an IC50 of 0.04 μM, achieving 95% maximum reduction[1].
CK147 (0.01-100 μM; 72 h) is cytotoxic to HEK293T cells with a CC50 of 0.36 μM, significantly reducing cell proliferation after 72 hours of treatment[1].
CK147 (0.01-100 μM; 72 h) inhibits proliferation of wild-type HCT116 cells with a CC50 of 0.48 μM, but has no effect on proliferation of CK147-resistant HCT116 clones, which have CC50 values >50 μM[1].
CK147 is the most potent identified CADA analog, down-modulating CD4 expression with an IC50 of 0.058 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human embryonic kidney (HEK) 293T cells
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Concentration:0.01, 0.1, 1, 10 and 100 μM
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Incubation Time:72 h
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Result:Reduces HEK293T cell proliferation in a concentration-dependent manner, with a cytotoxic concentration (CC50) of 0.36 μM.
Reduces proliferation to ≤ 10% of DMSO control levels at concentrations ≥ 0.1 μM.
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Cell Line:wild-type and CK147-resistant HCT116 human colon cancer cells
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Concentration:0.01, 0.1, 1, 10 and 100 μM
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Incubation Time:72 h
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Result:Inhibits proliferation of wild-type HCT116 cells, with a CC50 of 0.48 μM.
Shows no effect on proliferation of three CK147-resistant HCT116 clones (10, 13, 16), which have CC50 values > 50 μM and proliferation remaining near 100% of DMSO control across all tested concentrations.
Chemical Information
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CAS No. 1883356-12-4
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Masse moléculaire 616.88
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Formule C32H48N4O4S2
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SMILES
O=S(C1=CC=C(N(C)C)C=C1)(N2CC(CN(S(=O)(C3=CC=C(C)C=C3)=O)CCCN(CC4CCCCC4)CCC2)=C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CK147 Related Classifications
HY-182690 Related Classifications
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