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Cat. No.: HY-129485A

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CM304 free base

Name: CM304 free base
Brand: MedChemExpress
SKU: HY-129485A
Availability: PreOrder

(Synonyms: FTC-146)

CM304 free base (FTC-146) is a potent S1R antagonist. CM304 free base enhances the antinociceptive effects of the cannabinoid receptor agonists. CM304 free base inhibits convulsions in rats.

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CAS No.: 1350296-21-7
Formule: C₁₈H₂₅FN₂OS
Masse moléculaire:336.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CM304 free base Chemical Structure

CAS No.: 1350296-21-7

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Description

CM304 free base (FTC-146) is a potent S1R antagonist. CM304 free base enhances the antinociceptive effects of the cannabinoid receptor agonists. CM304 free base inhibits convulsions in rats^[1]^[2].

IC₅₀ & Target

^[1]^[2]

Sigma 1 Receptor

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Chemical Information

CAS No. 1350296-21-7
Masse moléculaire 336.47
Formule C₁₈H₂₅FN₂OS
SMILES

O=C1SC2=CC(CCCF)=CC=C2N1CCN3CCCCCC3
Synonyms

FTC-146
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Avery BA, et al. Quantification of highly selective sigma-1 receptor antagonist CM304 using liquid chromatography tandem mass spectrometry and its application to a pre-clinical pharmacokinetic study. Drug Test Anal. 2017 Aug;9(8):1236-1242. [Content Brief]

[2]. Patel A, et al. The Sigma1 Receptor Antagonist CM304 Enhances the Antinociceptive Effects of the Cannabinoid Receptor Agonists, but not Mu‐Opioid Receptor Full Agonists in Mice[J]. The FASEB Journal, 2020, 34(S1): 1-1.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CM304 free base

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