Tcf7l2 - transcription factor 7 like 2, T cell specific, HMG box Gene

Also Known as Tcf4; TCF4B; TCF4E; Tcf-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21416

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of Insulin secretion; regulation of transcription, DNA-templated; and response to glucose. Acts upstream of or within several processes, including animal organ development; negative regulation of cellular response to growth factor stimulus; and regulation of cellular biosynthetic process. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate Cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Tcf7l2 Products (31)

mRNA Protein Name
NM_001142918.2 NP_001136390.1 transcription factor 7-like 2 isoform 1
NM_001142919.2 NP_001136391.1 transcription factor 7-like 2 isoform 2
NM_001142920.2 NP_001136392.1 transcription factor 7-like 2 isoform 4
NM_001142921.2 NP_001136393.1 transcription factor 7-like 2 isoform 5
NM_001142922.2 NP_001136394.1 transcription factor 7-like 2 isoform 6
NM_001142923.2 NP_001136395.1 transcription factor 7-like 2 isoform 7
NM_001142924.2 NP_001136396.1 transcription factor 7-like 2 isoform 8
NM_001331135.1 NP_001318064.1 transcription factor 7-like 2 isoform 9
NM_001331136.1 NP_001318065.1 transcription factor 7-like 2 isoform 10
NM_001331137.1 NP_001318066.1 transcription factor 7-like 2 isoform 11
NM_001331138.1 NP_001318067.1 transcription factor 7-like 2 isoform 12
NM_001331139.1 NP_001318068.1 transcription factor 7-like 2 isoform 13
NM_001331140.1 NP_001318069.1 transcription factor 7-like 2 isoform 14
NM_001331141.1 NP_001318070.1 transcription factor 7-like 2 isoform 15
NM_001331142.1 NP_001318071.1 transcription factor 7-like 2 isoform 16
NM_001331143.1 NP_001318072.1 transcription factor 7-like 2 isoform 17
NM_001331144.1 NP_001318073.1 transcription factor 7-like 2 isoform 18
NM_001331145.1 NP_001318074.1 transcription factor 7-like 2 isoform 19
NM_001331146.1 NP_001318075.1 transcription factor 7-like 2 isoform 20
NM_001331147.1 NP_001318076.1 transcription factor 7-like 2 isoform 21
NM_001331148.1 NP_001318077.1 transcription factor 7-like 2 isoform 22
NM_001331149.1 NP_001318078.1 transcription factor 7-like 2 isoform 23
NM_001331150.1 NP_001318079.1 transcription factor 7-like 2 isoform 24
NM_001412695.1 NP_001399624.1 transcription factor 7-like 2 isoform 10
NM_001412705.1 NP_001399634.1 transcription factor 7-like 2 isoform 25
NM_001412706.1 NP_001399635.1 transcription factor 7-like 2 isoform 26
NM_001412707.1 NP_001399636.1 transcription factor 7-like 2 isoform 27
NM_001412708.1 NP_001399637.1 transcription factor 7-like 2 isoform 28
NM_001412710.1 NP_001399639.1 transcription factor 7-like 2 isoform 29
NM_001412711.1 NP_001399640.1 transcription factor 7-like 2 isoform 5
NM_009333.4 NP_033359.2 transcription factor 7-like 2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20044351 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20044351 MGI
enables beta-catenin binding IDA
IDA: Inferred from direct assay
9784592 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
9488439 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
17727834 MGI
enables chromatin binding IGI
IGI: Inferred from genetic interaction
23824574 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9488439 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20044351 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
17919533 MGI
acts upstream of or within bone mineralization IGI
IGI: Inferred from genetic interaction
19213727 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
9488439 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
17699607 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
10937998 MGI
acts upstream of or within cellular response to starvation IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within embryonic digestive tract morphogenesis IGI
IGI: Inferred from genetic interaction
15057272 MGI
acts upstream of or within embryonic genitalia morphogenesis IGI
IGI: Inferred from genetic interaction
15057272 MGI
acts upstream of or within embryonic hindgut morphogenesis IGI
IGI: Inferred from genetic interaction
15057272 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19251639 MGI
acts upstream of or within face morphogenesis IGI
IGI: Inferred from genetic interaction
17699607 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17919533 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
23028378 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
acts upstream of or within insulin metabolic process IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within intracellular glucose homeostasis IMP
IMP: Inferred from mutant phenotype
23028378 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within myoblast fate commitment IMP
IMP: Inferred from mutant phenotype
10937998 MGI
acts upstream of or within negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
17919533 MGI
acts upstream of or within negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
10937998 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17919533 MGI
acts upstream of or within negative regulation of organ growth IMP
IMP: Inferred from mutant phenotype
17919533 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
15057272 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
17699607 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
19741146 MGI
acts upstream of organ growth IMP
IMP: Inferred from mutant phenotype
17919533 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
17919533 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19168596 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17919533 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19251639 MGI
acts upstream of or within positive regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
23260145 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
19168596 MGI
acts upstream of or within positive regulation of lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20044351 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21335239 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15778706 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within positive regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
23260145 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12861022 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
23028378 MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19168596 MGI
acts upstream of or within regulation of myelination IMP
IMP: Inferred from mutant phenotype
19503085 MGI
acts upstream of or within regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19503085 MGI
acts upstream of or within regulation of skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
21177349 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19168596 MGI
involved in response to glucose IMP
IMP: Inferred from mutant phenotype
19168596 MGI
acts upstream of or within secretory granule localization IMP
IMP: Inferred from mutant phenotype
19168596 MGI
acts upstream of or within skin development IGI
IGI: Inferred from genetic interaction
19718027 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: Inferred from genetic interaction
19718027 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
9697701 MGI
Cellular Component GO Annotation Evidence Références Source
part of catenin-TCF7L2 complex IDA
IDA: Inferred from direct assay
9488439 MGI
located in cytosol IDA
IDA: Inferred from direct assay
15578569 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9697701 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12861022 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor 7-like 2

  • HMG box transcription factor 4

  • HMG box transcription factor TCF7L2

  • T-cell-specific transcription factor 4

Tcf7l2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Tcf7l2 Q924A0 Hic1 Mus musculus Q9R1Y5
Anti Bait CoIP
16724116
Intra
Tcf7l2 Q924A0 Hic1 Mus musculus Q9R1Y5
Anti Tag CoIP
16724116
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-W010995 2,5-Dimethylcelecoxib Inhibitor 99.57% Unkown
HY-N3628 Coronarin A Inhibitor ≥98.0% Unkown
HY-RS14310 TCF7L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17858 Tcf7l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24327 Tcf7l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcf7l2 NCBI NCBI:6934