Hic1 - hypermethylated in cancer 1 Gene

Also Known as HIC-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15248

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hic1 Products (2)

mRNA Protein Name
NM_001098203.1 NP_001091673.1 hypermethylated in cancer 1 protein isoform 2
NM_010430.3 NP_034560.3 hypermethylated in cancer 1 protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16269335 MGI
Biological Process GO Annotation Evidence References Source
involved in intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: Inferred from direct assay
16269335 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16269335 MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
16269335 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
16269335 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hypermethylated in cancer 1 protein

Hic1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hic1 Q9R1Y5 Sirt1 Mus musculus Q923E4
Anti Bait CoIP
16269335
Intra
Hic1 Q9R1Y5 Tcf7l2 Mus musculus Q924A0
Anti Bait CoIP
16724116
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W540188A Calcium mesoxalate trihydrate 98.5% Unkown
HY-RS06165 HIC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hic1 NCBI NCBI:3090