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Gsk3b - glycogen synthase kinase 3 beta Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84027

Summary

Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including regulation of neuron projection development; regulation of synapse organization; and response to peptide. Located in several cellular components, including dendritic spine; membrane raft; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); diabetic encephalopathy; mental depression; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3b Products (1)

mRNA	Protein	Name
NM_032080.1	NP_114469.1	glycogen synthase kinase-3 beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16879317	RGD
enables integrin binding	IPI IPI: Inferred from physical interaction	18677563	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	17329210	RGD
enables kinase activity	IDA IDA: Inferred from direct assay	1346104	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9482734	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16478782	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	2164470	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	8524413	RGD
enables tau protein binding	IDA IDA: Inferred from direct assay	16735023	RGD
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	16735023	RGD

Biological Process GO Annotation	Evidence	Références	Source
involved in bone remodeling	IDA IDA: Inferred from direct assay	29224185	RGD
involved in cell growth involved in cardiac muscle cell development	IDA IDA: Inferred from direct assay	27854077	RGD
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	26224839	RGD
involved in cellular response to dopamine	IEP IEP: Inferred from expression pattern	20007479	RGD
involved in cellular response to erythropoietin	IEP IEP: Inferred from expression pattern	17952604	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	18005341	RGD
involved in cellular response to iron(II) ion	IEP IEP: Inferred from expression pattern	19608791	RGD
involved in cellular response to lithium ion	IEP IEP: Inferred from expression pattern	18932008	RGD
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	20042609	RGD
involved in establishment of cell polarity	IDA IDA: Inferred from direct assay	12610628	RGD
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	15652487	RGD
involved in establishment or maintenance of cell polarity	IDA IDA: Inferred from direct assay	12610628	RGD
involved in hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	28061416	RGD
involved in hepatocyte apoptotic process	IDA IDA: Inferred from direct assay	28638224	RGD
involved in maintenance of cell polarity	IMP IMP: Inferred from mutant phenotype	15652487	RGD
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17182785	RGD
involved in negative regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	23470087	RGD
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	17182785	RGD
involved in negative regulation of dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	15522889	RGD
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	8524413	RGD
involved in negative regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	11403684	RGD
involved in negative regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	18005341	RGD
involved in negative regulation of protein acetylation	IMP IMP: Inferred from mutant phenotype	18268107	RGD
involved in negative regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	23624080	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	21557011	RGD
involved in negative regulation of synaptic assembly at neuromuscular junction	IMP IMP: Inferred from mutant phenotype	25764078	RGD
involved in neuron projection organization	IMP IMP: Inferred from mutant phenotype	15652487	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	12721208	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12393899	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12808104	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	20007479	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	19318234	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16765055	RGD
involved in positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	26722385	RGD
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	28731198	RGD
involved in positive regulation of osteoclast proliferation	IMP IMP: Inferred from mutant phenotype	26722385	RGD
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	17686886	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21557011	RGD
involved in positive regulation of synaptic assembly at neuromuscular junction	IMP IMP: Inferred from mutant phenotype	25764078	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11035810	RGD
involved in regulation of axon extension	IMP IMP: Inferred from mutant phenotype	15652487	RGD
involved in regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	15652487	RGD
involved in regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	15652487	RGD
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18268107	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	23864697	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	23864697	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17329210	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	23864697	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	23864697	RGD
involved in regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	28731198	RGD
involved in response to L-glutamate	IEP IEP: Inferred from expression pattern	18445133	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	22252247	RGD
involved in response to angiotensin	IEP IEP: Inferred from expression pattern	22982863	RGD
involved in response to epinephrine	IEP IEP: Inferred from expression pattern	16934435	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	22252247	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	16934435	RGD
involved in response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	17686886	RGD
involved in response to ultrasound	IEP IEP: Inferred from expression pattern	20708505	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19359144	RGD
involved in response to zinc ion	IDA IDA: Inferred from direct assay	27295130	RGD

Cellular Component GO Annotation	Evidence	Références	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	23864697	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	23864697	RGD
located in axon	IDA IDA: Inferred from direct assay	15652487	RGD
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	10228155	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15652487	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	17329210	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23864697	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23864697	RGD
located in membrane	IDA IDA: Inferred from direct assay	16815997	RGD
located in microtubule	IDA IDA: Inferred from direct assay	8576078	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17329210	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
glycogen synthase kinase-3 beta	FA GSK-3 beta factor A serine/threonine-protein kinase GSK3B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N0657	Pinoresinol Diglucoside		99.84%	Unkown
HY-112388	GSK-3b Inhibitor XI	Inhibitor	99.10%	Unkown
HY-184447	RN193	Inhibitor	/	Unkown
HY-RS05865	GSK3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183955	GNF7156	Inhibitor	/	Unkown
HY-RS17170	Gsk3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23620	Gsk3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsk3b	NCBI	NCBI:2932