GSK3B - glycogen synthase kinase 3 beta Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2932

About GSK3B

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,821,321-120,094,447 (from NCBI)

This gene has 69 transcripts (splice variants), 228 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 13.9), thyroid (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

GSK3B Products (6)

mRNA	Protein	Name
NM_001146156.2	NP_001139628.1	glycogen synthase kinase-3 beta isoform 2
NM_001354596.2	NP_001341525.1	glycogen synthase kinase-3 beta isoform 3
NM_002093.4	NP_002084.2	glycogen synthase kinase-3 beta isoform 1
NM_001146156.2	NP_001139628.1	glycogen synthase kinase-3 beta isoform 2
NM_001354596.2	NP_001341525.1	glycogen synthase kinase-3 beta isoform 3
NM_002093.4	NP_002084.2	glycogen synthase kinase-3 beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	15465828	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20864106	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	8638126	GOA
enables dynactin binding	IPI IPI: Inferred from physical interaction	17139249	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	15448698	GOA
enables p53 binding	IDA IDA: Inferred from direct assay	14744935	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	25118933	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8638126	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	11035810	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	16981698	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18348280	GOA
enables protein serine kinase activity	IGI IGI: Inferred from genetic interaction	30556160	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8638126	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16981698	GOA
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	14690523	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21118991	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ER overload response	IDA IDA: Inferred from direct assay	14744935	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10428961	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	28122350	GOA
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	15448698	GOA
involved in glycogen metabolic process	IDA IDA: Inferred from direct assay	8638126	GOA
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	19581563	GOA
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	14749367	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25118933	GOA
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	14744935	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	9072970	GOA
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	27846906	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24023731	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	27494834	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	15448698	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	18846110	GOA
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27050373	GOA
involved in negative regulation of mesenchymal stem cell differentiation	IMP IMP: Inferred from mutant phenotype	24023731	GOA
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	24023731	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	16188939	GOA
involved in neuron projection development	IDA IDA: Inferred from direct assay	19830702	GOA
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	11104755	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	8638126	GOA
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	30556160	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	11955436	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	18156211	GOA
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	28122350	GOA
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	18156211	GOA
acts upstream of positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26315788	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19364825	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25897075	GOA
acts upstream of or within positive regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	14744935	GOA
involved in positive regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	17139249	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	29142209	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	8638126	GOA
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	17989287	GOA
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17989287	GOA
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17989287	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	23184662	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11035810	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16981698	GOA
involved in regulation of microtubule anchoring at centrosome	IMP IMP: Inferred from mutant phenotype	17139249	GOA
involved in regulation of microtubule-based process	IMP IMP: Inferred from mutant phenotype	20937854	GOA
involved in regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	12223487	GOA
involved in superior temporal gyrus development	IMP IMP: Inferred from mutant phenotype	19581563	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	8638126	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17139249	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12223487	GOA
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17989287	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17989287	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17989287	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12223487	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20937854	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSK3B Protein Structure

STKc_GSK3

0
100
200
300
400
420 a.a.

Protein Preferred Names	Protein Names
glycogen synthase kinase-3 beta	GSK-3 beta

GSK3B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GSK3B	P49841	SNAI1	Homo sapiens	O95863	Anti Bait CoIP	19411070
Intra	GSK3B	P49841	CABYR	Homo sapiens	O75952-5	Protein Kinase Assay	15752768
Intra	GSK3B	P49841	CABYR	Homo sapiens	O75952-5	Pull Down	15752768
Intra	GSK3B	P49841	CABYR	Homo sapiens	O75952-5	Y2H	15752768
Intra	GSK3B	P49841	CABYR	Homo sapiens	O75952-3	Y2H	15752768
Intra	GSK3B	P49841	CABYR	Homo sapiens	O75952-3	Pull Down	15752768
Intra	GSK3B	P49841	CABYR	Homo sapiens	O75952-3	Protein Kinase Assay	15752768
Intra	GSK3B	P49841	BICD1	Homo sapiens	Q96G01	Anti Tag CoIP	17139249
Intra	GSK3B	P49841	BICD1	Homo sapiens	Q96G01	Pull Down	17139249
Cross	GSK3B	P49841	Disc1	Mus musculus	Q811T9	SPR	19303846
Cross	GSK3B	P49841	Disc1	Mus musculus	Q811T9	Protein Kinase Assay	19303846
Intra	GSK3B	P49841	AKT2	Homo sapiens	P31751	X-Ray Diffraction	12434148
Intra	GSK3B	P49841	AKT1	Homo sapiens	P31749	Anti Tag CoIP	23010592
Intra	GSK3B	P49841	RELB	Homo sapiens	Q01201	Anti Bait CoIP	21217772
Intra	GSK3B	P49841	UBR5	Homo sapiens	O95071	Pull Down	21118991
Intra	GSK3B	P49841	UBR5	Homo sapiens	O95071	Anti Tag CoIP	21118991
Intra	GSK3B	P49841	UBR5	Homo sapiens	O95071	Confocal	21118991
Intra	GSK3B	P49841	UBR5	Homo sapiens	O95071	Anti Bait CoIP	21118991
Intra	GSK3B	P49841	TP53	Homo sapiens	P04637	Protein Kinase Assay	14744935
Intra	GSK3B	P49841	TP53	Homo sapiens	P04637	Anti Bait CoIP	14744935
Intra	GSK3B	P49841	MAPT	Homo sapiens	P10636-8	Protein Kinase Assay	24165324
Intra	GSK3B	P49841	MAPT	Homo sapiens	P10636-8	Anti Tag CoIP	24165324
Intra	GSK3B	P49841	MAPT	Homo sapiens	P10636-8	Protein Kinase Assay	21985244
Intra	GSK3B	P49841	FRAT1	Homo sapiens	Q92837	Protein Kinase Assay	10481074
Intra	GSK3B	P49841	FRAT1	Homo sapiens	Q92837	TAP	23602568
Intra	GSK3B	P49841	FRAT1	Homo sapiens	Q92837	Pull Down	29568061
Intra	GSK3B	P49841	FRAT1	Homo sapiens	Q92837	TAP	23455922
Intra	GSK3B	P49841	ZFPM1	Homo sapiens	Q8IX07	Y2H	21988832
Intra	GSK3B	P49841	DACT1	Homo sapiens	Q9NYF0	Confocal	22470507
Cross	GSK3B	P49841	Mapk1	Mus musculus	P63085	Protein Kinase Assay	18045539
Cross	GSK3B	P49841	Ctnnb1	Mus musculus	Q02248	Protein Kinase Assay	10481074
Cross	GSK3B	P49841	Ctnnb1	Mus musculus	Q02248	Protein Kinase Assay	12421363
Cross	GSK3B	P49841	Axin1	Mus musculus	Q14DJ8	Anti Tag CoIP	21242974
Cross	GSK3B	P49841	Axin1	Mus musculus	Q14DJ8	Pull Down	21242974
Intra	GSK3B	P49841	AXIN2	Homo sapiens	Q9Y2T1	Pull Down	29568061
Intra	GSK3B	P49841	AXIN2	Homo sapiens	Q9Y2T1	TAP	23602568
Intra	GSK3B	P49841	AXIN2	Homo sapiens	Q9Y2T1	TAP	23455922
Intra	GSK3B	P49841	AXIN2	Homo sapiens	Q9Y2T1	Pull Down	32707033
Intra	GSK3B	P49841	EIF2B5	Homo sapiens	Q13144	Protein Kinase Assay	10481074
Intra	GSK3B	P49841	PRKACA	Homo sapiens	P17612	Anti Tag CoIP	11035810
Intra	GSK3B	P49841	PRKACA	Homo sapiens	P17612	BioID	29568061
Intra	GSK3B	P49841	PRKACA	Homo sapiens	P17612	TAP	23602568
Intra	GSK3B	P49841	PRKACA	Homo sapiens	P17612	Pull Down	29568061
Intra	GSK3B	P49841	CTNNB1	Homo sapiens	P35222	BioID	29568061
Intra	GSK3B	P49841	CTNNB1	Homo sapiens	P35222	PLA	25241761
Intra	GSK3B	P49841	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	18687691
Intra	GSK3B	P49841	CTNNB1	Homo sapiens	P35222	TAP	23602568
Intra	GSK3B	P49841	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	8638126
Intra	GSK3B	P49841	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	8638126
Intra	GSK3B	P49841	CTNNB1	Homo sapiens	P35222	Protein Kinase Assay	19303846
Intra	GSK3B	P49841	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	24165324
Intra	GSK3B	P49841	LRRK2	Homo sapiens	Q5S007	Anti Bait CoIP	24165324
Intra	GSK3B	P49841	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	24165324
Intra	GSK3B	P49841	STYK1	Homo sapiens	Q6J9G0	Anti Tag CoIP	23010592
Intra	GSK3B	P49841	TRIM29	Homo sapiens	Q14134	Anti Bait CoIP	19249679
Intra	GSK3B	P49841	GYS1	Homo sapiens	P13807	Protein Kinase Assay	24165324
Intra	GSK3B	P49841	GYS1	Homo sapiens	P13807	Protein Kinase Assay	16282323
Intra	GSK3B	P49841	GYS1	Homo sapiens	P13807	Protein Kinase Assay	10481074
Intra	GSK3B	P49841	NBR1	Homo sapiens	Q14596	Protein Kinase Assay	24879152
Intra	GSK3B	P49841	NBR1	Homo sapiens	Q14596	Pull Down	24879152
Intra	GSK3B	P49841	NBR1	Homo sapiens	Q14596	BioID	29568061
Intra	GSK3B	P49841	LRP6	Homo sapiens	O75581	Anti Tag CoIP	16365045
Intra	GSK3B	P49841	DAB2IP	Homo sapiens	Q5VWQ8-2	Anti Bait CoIP	20080667
Intra	GSK3B	P49841	DAB2IP	Homo sapiens	Q5VWQ8-2	Anti Tag CoIP	20080667
Intra	GSK3B	P49841	SNCA	Homo sapiens	P37840	Pull Down	21985244

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GSK3B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74114	GSK-3 beta Protein, Human (Active, sf9, His)	P49841-2/NP_002084.2 (M1-T433)	≥ 90%, as determined by reducing SDS-PAGE.

GSK3B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80462	Phospho-GSK3 beta(Ser 9) Antibody (YA192)	WB, ICC/IF, IHC-P	Human
HY-P80698	GSK3 beta Antibody (YA744)	WB, IHC-P, FC	Human, Mouse, Rat
HY-P80820	Phospho-GSK3 beta (Ser9) Antibody (YA193)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P80820A	Phospho-GSK3 beta (Ser9) Antibody (YA193)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84359	GSK3 beta Antibody (YA4056)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P84359A	GSK3 beta Antibody (YA4056)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
HY-P86094	GSK3 beta Antibody (YA5786)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86595	Phospho-GSK3 beta(Ser9) Antibody (YA6287)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Polyposis Coli Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Alzheimer Disease 9	AD9 Alzheimer'S Disease 9 Alzheimer Disease 9, Susceptibility To Alzheimer Disease 9, Late-Onset Alzheimer'S Disease 9, Late Onset {Alzheimer Disease 9, Susceptibility To}
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Cervical Non-Keratinizing Squamous Cell Carcinoma
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Fallopian Tube Serous Adenocarcinoma
Diabetes Mellitus	Diabetes
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0657	Pinoresinol Diglucoside		99.84%	Unkown
HY-112388	GSK-3b Inhibitor XI	Inhibitor	99.10%	Unkown
HY-184447	RN193	Inhibitor	/	Unkown
HY-RS05865	GSK3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183955	GNF7156	Inhibitor	/	Unkown
HY-RS17170	Gsk3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23620	Gsk3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GSK3B	VGNC	VGNC:73298
Canis familiaris	GSK3B	VGNC	VGNC:41530
Mus musculus	GSK3B	MGD	MGI:1861437
Felis catus	GSK3B	VGNC	VGNC:102751
Rattus norvegicus	GSK3B	RGD	RGD:70982
Bos taurus	GSK3B	VGNC	VGNC:106762
Others	GSK3B	NCBI