Hexoprenaline sulfate
Hexoprenaline sulfate is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline sulfate can dilate the bronchi. Hexoprenaline sulfate can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline sulfate exhibits anti-infection and anti-inflammmation effect. Hexoprenaline sulfate can increase placental weight and blood flow. Hexoprenaline sulfate can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds.
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- CAS No.: 32266-10-7
- Formule: C22H34N2O10S
- Masse moléculaire:518.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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β-adrenoceptor |
Hexoprenaline (10 nM-1 mM) sulfate activates adenylate cyclase in isolated rat gastric mucosal cells[2].
Hexoprenaline (10-10000 nM) sulfate increasingly stimulate 14C-Aminopyrine uptake in isolated rat gastric mucosal cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hexoprenaline (0.5 mg diet, p.o., daily) sulfate increases placental weight and blood flow in blood flow[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with E. coli O157:H7-induced sepsis[3]
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Dosage:1.5 mg/kg
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Administration:Subcutaneous injection
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Result:Reduced the mortality by 1.98-fold at 4 h and by 1.56-fold at 24 h.
Decreased plasma TNF-α, IL-1β, and IL-6 concentrations.
Chemical Information
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CAS No. 32266-10-7
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Masse moléculaire 518.58
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Formule C22H34N2O10S
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SMILES
OC(CNCCCCCCNCC(O)C1=CC=C(C(O)=C1)O)C2=CC=C(C(O)=C2)O.OS(O)(=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Schonell M, et al. Bronchodilator effect of hexoprenaline aerosol in bronchial asthma and chronic bronchitis. Med J Aust. 1977 Dec 17;2(25):828-30. [Content Brief]
[2]. Ruoff HJ, et al. Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and 14C-aminopyrine uptake. Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):175-81. [Content Brief]
[5]. Lipshitz J, et al. Effect of long-term administration of beta 2-sympathomimetic drug in the diet-restricted pregnant rat model. Am J Obstet Gynecol. 1986 Feb;154(2):314-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hexoprenaline sulfate Related Classifications
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