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Cat. No.: HY-162703

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Lipid-lowering agent-2

Lipid-lowering agent-2 (Compound 14d) is an orally active lipid-lowering agent with an EC₅₀ of 0.06 μM. Lipid-lowering agent-2 inhibits the lipid synthesis, activates the AMPK signaling pathway, and exhibits anti-obesity effect. Lipid-lowering agent-2 inhibits food intake, improves the glucose metabolism, and reduces the body weight and adipose tissue in high-fat diet (HFD)-induced obese mice.

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Formule: C₂₅H₂₇N₇O
Masse moléculaire:441.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Lipid-lowering agent-2 Chemical Structure

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform AMPK :

Cellular Effect

Cell Line	Type	Value	Description	References
3T3-L1	CC₅₀	34.3 μM Compound: 14d	Cytotoxicity against confluent mouse 3T3-L1 preadipocytes assessed as reduction in cell viability measured after 24 hrs by SRB method Cytotoxicity against confluent mouse 3T3-L1 preadipocytes assessed as reduction in cell viability measured after 24 hrs by SRB method	[PMID: 38996004]
3T3-L1	EC₅₀	0.06 μM Compound: 14d	Lipid lowering activity in confluent mouse 3T3-L1 preadipocytes assessed as reduction in triglyceride level incubated for 9 days by oil red o staining based analysis Lipid lowering activity in confluent mouse 3T3-L1 preadipocytes assessed as reduction in triglyceride level incubated for 9 days by oil red o staining based analysis	[PMID: 38996004]

Chemical Information

Masse moléculaire 441.53
Formule C₂₅H₂₇N₇O
SMILES

O=C(N/N=C/C1=C(NC2=CC=CC=C21)C3=NC4=C(C(NCCN5CCCC5)=N3)C=CC=C4)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jiang Z, et al., Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group. J Med Chem. 2024 Jul 12. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Pureté et documentation
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Lipid-lowering agent-2

Voir tous les produits spécifiques à Isoform AMPK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Lipid-lowering agent-2 Related Classifications

HY-162703 Related Classifications