LSD1-IN-50
LSD1-IN-50 is a lysine-specific histone demethylase 1 (LSD1) inhibitor. LSD1-IN-50 inhibits the proliferation of Kasumi-1 leukemia cells and shows binding affinity to LSD-1. LSD1-IN-50 can be used for the study of cancer, particularly leukemia.
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- CAS No.: 1340824-39-6
- Formule: C23H22N6O
- Masse moléculaire:398.46
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
LSD1-IN-50 (compound L02) (25 μM) shows LSD-1 enzymatic inhibition with an inhibition rate of 40.49%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1340824-39-6
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Appearance Solid
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Masse moléculaire 398.46
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Formule C23H22N6O
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Color White to off-white
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SMILES
N#CC1=CC=C(C2=NC(C3=CC(N=CN4CCN5CCCCC5)=C4C=C3)=NO2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
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Fiche technique (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1-IN-50 Related Classifications
HY-188077 Related Classifications
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