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Cat. No.: HY-W1052192D

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mPEG2000-DMPE sodium

mPEG2000-DMPE sodium is a pegylated lipid with a methyl group at the opposite end of the PEG chain, and can be used for the preparation of lipid nanoparticles or liposomes for targeted drug delivery applications. mPEG2000-DMPE sodium is applicable for siRNA-related application studies targeting macrophages and dendritic cells.

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CAS No.: 384835-59-0
Masse moléculaire:2000 (Average)

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Please store the product under the recommended conditions in the Certificate of Analysis.

mPEG2000-DMPE sodium Chemical Structure

CAS No.: 384835-59-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
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Activité biologique

Description

In Vitro

Lipid nanoparticles containing mPEG2000-DMPE sodium (6.25-50 nmol/L; 2 days) deliver CD45 siRNA to murine inflammatory peritoneal macrophages to induce dose-dependent knock-down of CD45 mRNA (up to 91% suppression) and protein (up to 56% suppression) in vitro^[1].
Lipid nanoparticles containing mPEG2000-DMPE sodium (50 nmol/L; 3 days) deliver CD45 siRNA to human monocyte-derived macrophages to induce 70% suppression of CD45 mRNA and 20% suppression of CD45 protein in vitro^[1].
Lipid nanoparticles containing mPEG2000-DMPE sodium (50 nmol/L; 3 days) deliver CD45 siRNA to human monocyte-derived dendritic cells to induce 50% suppression of CD45 mRNA and 30% suppression of CD45 protein in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LNP containing mPEG2000-DMPE sodium (1 mg/kg; i.v.; 3 separate occasions at 2-day intervals) delivers CD45 siRNA to produce a 30% reduction in CD45 cell surface expression on murine splenic macrophages and dendritic cells following intravenous administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 384835-59-0
Masse moléculaire 2000 (Average)
SMILES

[H][C@](COP(OCCNC(OCCOC)=O)(O[Na])=O)(COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O.[n]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Uemura Y, et al.. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages and dendritic cells. Pharmaceutical development and technology. 2019 Mar;24(3):263-268. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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