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Cat. No.: HY-N11479

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Vallesiachotamine

Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity.

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CAS No.: 5523-37-5
Formule: C₂₁H₂₂N₂O₃
Masse moléculaire:350.41

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Vallesiachotamine Chemical Structure

CAS No.: 5523-37-5

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	26 μM Compound: 11	Cytotoxic activity against human A549 cells after 48 hrs by MTT assay Cytotoxic activity against human A549 cells after 48 hrs by MTT assay	[PMID: 20041704]
HL-60	IC₅₀	2 μM Compound: 11	Cytotoxic activity against human HL60 cells after 48 hrs by MTT assay Cytotoxic activity against human HL60 cells after 48 hrs by MTT assay	[PMID: 20041704]
KB	ED₅₀	3.56 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 7334384]
P388	ED₅₀	1.1 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 7334384]
SK-BR-3	IC₅₀	24.7 μM Compound: 11	Cytotoxic activity against human SK-BR-3 cells after 48 hrs by MTT assay Cytotoxic activity against human SK-BR-3 cells after 48 hrs by MTT assay	[PMID: 20041704]
SMMC-7721	IC₅₀	16.8 μM Compound: 11	Cytotoxic activity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxic activity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 20041704]

In Vitro

Vallesiachotamine induces G0/G1 arrest and increased the proportion of sub-G1 hypodiploid cells (at 11 μM and 22 μM) and this effect is not dependent on time of incubation. Vallesiachotamine acts by promoting G0/G1 cell cycle arrest, apoptosis and necrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 5523-37-5
Masse moléculaire 350.41
Formule C₂₁H₂₂N₂O₃
SMILES

C/C=C([C@@H]1C[C@@]2([H])C3=C(CCN2C=C1C(OC)=O)C4=CC=CC=C4N3)/C=O
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Paula R O Soares, et al. In vitro antiproliferative effects of the indole alkaloid vallesiachotamine on human melanoma cells. Paula R O Soares. 2012 Mar;35(3):565-71. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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