1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Camptothecin-20(S)-O-propionate

Camptothecin-20(S)-O-propionate (Synonyms: Camptothecin-20-O-propionate)

Cat. No.: HY-114668
Handling Instructions

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.

For research use only. We do not sell to patients.

Camptothecin-20(S)-O-propionate Chemical Structure

Camptothecin-20(S)-O-propionate Chemical Structure

CAS No. : 194414-69-2

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Description

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].

In Vivo

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3].

Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3].
Dosage: 100-1000 mg/kg/day.
Administration: Oral gavage, for 2, 4 and 6 days, respectively.
Result: Exhibited anti-tumor effect.
Molecular Weight

404.42

Formula

C₂₃H₂₀N₂O₅

CAS No.

194414-69-2

SMILES

O=C1[[email protected]](CC)(C2=C(C(N3CC4=CC5=CC=CC=C5N=C4C3=C2)=O)CO1)OC(CC)=O

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Keywords:

Camptothecin-20(S)-O-propionateCamptothecin-20-O-propionateTopoisomeraseCLObreastcarcinomaPC3prostateInhibitorinhibitorinhibit

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