194414-69-2
194414-69-2
Chemical Structure
Camptothecin-20(S)-O-propionate
Synonym(s): Camptothecin-20-O-propionate
- CAS. Nr.: 194414-69-2
- Formula:C23H20N2O5
- Molecular Weight:404.42
IUPAC Name: (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl propionate
InChIKey: YCNIQYLWIPCLNY-QHCPKHFHSA-N
SMILES: O=C1[C@](CC)(C2=C(C(N3CC4=CC5=CC=CC=C5N=C4C3=C2)=O)CO1)OC(CC)=O
Biological Activity: Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Camptothecin-20(S)-O-propionate | 99.60% | Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-114668ACamptothecin-20(S)-O-propionate hydrate -
Similarity Score 0.92
HY-W89765520-O-Acetylcamptothecin -
Similarity Score 0.81
HY-145290CPT-Se3 -
Similarity Score 0.81
HY-182071MG16 -
Similarity Score 0.81
HY-16560Camptothecin -
Similarity Score 0.81
HY-16560B(R)-Camptothecin -
Similarity Score 0.80
HY-145291CPT-Se4 -
Similarity Score 0.79
HY-N1294418-Hydroxycamptothecin -
Similarity Score 0.74
HY-N044610-Methoxycamptothecin -
Explore the MedChemAI to find more analogs
References
- [1]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206. [Content Brief]
- [2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. [Content Brief]
