113122-54-6
Chemical Structure
Deoxysappanone B
Synonym(s): 3-Deoxysappanone B
- CAS No.: 113122-54-6
- Formula:C16H14O5
- Molecular Weight:286.28
IUPAC Name: (R)-3-(3,4-dihydroxybenzyl)-7-hydroxychroman-4-one
InChIKey: KCUXSQJYIWEGRG-SNVBAGLBSA-N
SMILES: O=C1[C@H](CC2=CC=C(O)C(O)=C2)COC3=CC(O)=CC=C13
Biological Activity: Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1].
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Deoxysappanone B | Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage. | |||||||||||||||||||||
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- [1]. Ke-Wu Zeng, et al. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Eur J Pharmacol. 2015 Feb 5;748:18-29. [Content Brief]
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